visualizations
Smith, Steven R, MD
Overview
research areas
- Biochemistry & Molecular Biology
- Cardiovascular System & Cardiology
- Cell Biology
- Education & Educational Research
- Endocrinology & Metabolism
- General & Internal Medicine
- Genetics & Heredity
- Geriatrics & Gerontology
- Health Care Sciences & Services
- Life Sciences & Biomedicine - Other Topics
- Nutrition & Dietetics
- Physiology
- Radiology, Nuclear Medicine & Medical Imaging
- Research & Experimental Medicine
- Science & Technology - Other Topics
Publications
Most Recent Publications
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2024Aging human abdominal subcutaneous white adipose tissue at single cell resolution. AGING CELL.Full Text via DOI: 10.1111/acel.14287 PMID: 39141531
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202424-h energy expenditure in people with type 1 diabetes: impact on equations for clinical estimation of energy expenditure. EUROPEAN JOURNAL OF CLINICAL NUTRITION.Full Text via DOI: 10.1038/s41430-024-01446-4 PMID: 38745052
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2024Myokine Secretion following an Aerobic Exercise Intervention in Individuals with Type 2 Diabetes with or without Exercise Resistance. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25.Full Text via DOI: 10.3390/ijms25094889 PMID: 38732106
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2024Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 326:C1248-C1261.Full Text via DOI: 10.1152/ajpcell.00726.2023 PMID: 38581663
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2024An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25.Full Text via DOI: 10.3390/ijms25010437 PMID: 38203607
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2024Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women. CELLS. 13.Full Text via DOI: 10.3390/cells13010086 PMID: 38201289
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2023Implementation of digital cognitive assessment and blood Implementation of digital cognitive assessment and blood based biomarkers for early detection in Alzheimer's disease at Adventhealth: A Davos Alzheimer's collaborative flagship site. JOURNAL OF THE NEUROLOGICAL SCIENCES.Full Text via DOI: 10.1016/j.jns.2023.121365
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2023EARLY DETECTION IN ALZHEIMER′S DISEASE AT ADVENTHEALTH: A DAVOS ALZHEIMER′S COLLABORATIVE FLAGSHIP SITE. INNOVATION IN AGING. 852-853.
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2023Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 325:E291-E302.Full Text via DOI: 10.1152/ajpendo.00143.2023 PMID: 37584609
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2023Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial. NATURE COMMUNICATIONS. 14.Full Text via DOI: 10.1038/s41467-023-38778-x PMID: 37258525
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2023Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans. CELL REPORTS. 42.Full Text via DOI: 10.1016/j.celrep.2023.112218 PMID: 36897780
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2023Isolation of nuclei from frozen human subcutaneous adipose tissue for full-length single-nuclei transcriptional profiling. STAR PROTOCOLS. 4.Full Text via DOI: 10.1016/j.xpro.2023.102054 PMID: 36853719
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2023Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue. ISCIENCE. 26.Full Text via DOI: 10.1016/j.isci.2023.106189 PMID: 36895649
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2023Measurement of 24-h continuous human CH4 release in a whole room indirect calorimeter. JOURNAL OF APPLIED PHYSIOLOGY. 134:766-776.Full Text via DOI: 10.1152/japplphysiol.00705.2022 PMID: 36794690
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2023Glucagon-like peptide-1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial. OBESITY. 31:350-362.Full Text via DOI: 10.1002/oby.23633 PMID: 36695055
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2022Aerobic training increases mitochondrial respiratory capacity in human skeletal muscle stem cells from sedentary individuals. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 323:C606-C616.Full Text via DOI: 10.1152/ajpcell.00146.2022 PMID: 35785986
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2022Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. DRUGS-REAL WORLD OUTCOMES. 9:359-375.Full Text via DOI: 10.1007/s40801-022-00303-9 PMID: 35809196
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2022Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women. CELLS. 11.Full Text via DOI: 10.3390/cells11050848 PMID: 35269469
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2022Caloric restriction in humans reveals immunometabolic regulators of health span. SCIENCE. 375:671-+.Full Text via DOI: 10.1126/science.abg7292 PMID: 35143297
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2021A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity. JOURNAL OF THE ENDOCRINE SOCIETY. 5.Full Text via DOI: 10.1210/jendso/bvab118 PMID: 34337278
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2021Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training. DIABETOLOGIA.Full Text via DOI: 10.1007/s00125-021-05535-y PMID: 34402932
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2021Reliability of measurements of energy expenditure and substrate oxidation using whole-room indirect calorimetry. OBESITY.Full Text via DOI: 10.1002/oby.23226 PMID: 34355521
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2021DNA Methylation as a Marker of Body Shape in Premenopausal Women. FRONTIERS IN GENETICS. 12.Full Text via DOI: 10.3389/fgene.2021.709342 PMID: 34394195
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2021Developing a model for estimating the activity of colonic microbes after intestinal surgeries. PLOS ONE. 16.Full Text via DOI: 10.1371/journal.pone.0253542 PMID: 34319981
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2021Prolonged Glucagon Infusion Does Not Affect Energy Expenditure in Individuals with Overweight/Obesity: A Randomized Trial. OBESITY. 29:1003-1013.Full Text via DOI: 10.1002/oby.23141 PMID: 34029448
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2021Physiology of Energy Expenditure in the Weight-Reduced State. OBESITY. 29:S31-S38.Full Text via DOI: 10.1002/oby.23095 PMID: 33759394
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2021Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial. OBESITY SCIENCE & PRACTICE.Full Text via DOI: 10.1002/osp4.486 PMID: 34123395
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2021Chemical Oxygen Demand Can Be Converted to Gross Energy for Food Items Using a Linear Regression Model. JOURNAL OF NUTRITION. 151:445-453.Full Text via DOI: 10.1093/jn/nxaa321 PMID: 33188419
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2021A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. CIRCULATION. 143:145-159.Full Text via DOI: 10.1161/CIRCULATIONAHA.120.049813 PMID: 33106031
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2021Metabolic adaptation characterizes short-term resistance to weight loss induced by a low-calorie diet in overweight/obese individuals.. The American journal of clinical nutrition. 267-280.Full Text via DOI: 10.1093/ajcn/nqab027 PMID: 33826697
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2020Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance. CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS. 19.Full Text via DOI: 10.1016/j.conctc.2020.100646 PMID: 32875141
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2020Validity And Reliability Of Small Respiratory Chamber To Assess Exercise Energy Expenditure. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 43-43.
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2020An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. PHYSIOLOGICAL REPORTS. 8.Full Text via DOI: 10.14814/phy2.14416 PMID: 32562350
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2020Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure. JOURNAL OF THE ENDOCRINE SOCIETY. 4.Full Text via DOI: 10.1210/jendso/bvaa042 PMID: 32500109
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2020Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women. FRONTIERS IN PHYSIOLOGY. 11.Full Text via DOI: 10.3389/fphys.2020.00018 PMID: 32132925
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2019Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes. PHYSIOLOGICAL GENOMICS. 51:586-595.Full Text via DOI: 10.1152/physiolgenomics.00014.2019 PMID: 31588872
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2019Metabolic adaptation is not observed after 8 weeks of overfeeding but energy expenditure variability is associated with weight recovery. AMERICAN JOURNAL OF CLINICAL NUTRITION. 110:805-813.Full Text via DOI: 10.1093/ajcn/nqz108 PMID: 31204775
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2019Boosting NAD(+) with a small molecule that activates NAMPT. NATURE COMMUNICATIONS. 10.Full Text via DOI: 10.1038/s41467-019-11078-z PMID: 31324777
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2019GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. CELL METABOLISM. 29:707-+.Full Text via DOI: 10.1016/j.cmet.2018.12.016 PMID: 30639358
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2019Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial. CIRCULATION. 139:366-375.Full Text via DOI: 10.1161/CIRCULATIONAHA.118.038341 PMID: 30586726
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2019Objectively measured pediatric obesity prevalence using the OneFlorida Clinical Research Consortium. OBESITY RESEARCH & CLINICAL PRACTICE. 13:12-15.Full Text via DOI: 10.1016/j.orcp.2018.10.002 PMID: 30391132
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2018New Insights From Recent Large Trials. CIRCULATION. E770-E771.
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2018Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss A PCORnet Cohort Study. ANNALS OF INTERNAL MEDICINE. 169:741-+.Full Text via DOI: 10.7326/M17-2786 PMID: 30383139
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2018Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes. CLINICAL EPIGENETICS. 10.Full Text via DOI: 10.1186/s13148-018-0582-0 PMID: 30477572
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2018Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial. LANCET. 392:2269-2279.Full Text via DOI: 10.1016/S0140-6736(18)32328-6 PMID: 30293771
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2018Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes. DIABETES CARE. 41:2245-2254.Full Text via DOI: 10.2337/dc18-0296 PMID: 30072402
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2018Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms. ENDOCRINE REVIEWS. 629-663.Full Text via DOI: 10.1210/er.2017-00191 PMID: 30060120
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2018Cardiovascular Safety of Lorcaserin in Overweigh or Obese Patients. NEW ENGLAND JOURNAL OF MEDICINE. 379:1107-1117.Full Text via DOI: 10.1056/NEJMoa1808721 PMID: 30145941
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2018Genetic, epigenetic and transcriptional variations at NFATC2IP locus with weight loss in response to diet interventions: The POUNDS Lost Trial. DIABETES OBESITY & METABOLISM. 20:2298-2303.Full Text via DOI: 10.1111/dom.13333 PMID: 29693310
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2018HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI INSIGHT. 3.Full Text via DOI: 10.1172/jci.insight.120159 PMID: 30089714
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2018Characterization of adult obesity in Florida using the OneFlorida clinical research consortium. OBESITY SCIENCE & PRACTICE. 4:308-317.Full Text via DOI: 10.1002/osp4.274 PMID: 30151226
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2018Design and rationale for the Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61 (CAMELLIA-TIMI 61) trial. AMERICAN HEART JOURNAL. 202:39-48.Full Text via DOI: 10.1016/j.ahj.2018.03.012 PMID: 29803985
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2018Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training. FRONTIERS IN PHYSIOLOGY. 9.Full Text via DOI: 10.3389/fphys.2018.00704 PMID: 29942262
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2018Plasma fatty acyl-carnitines during 8 weeks of overfeeding: relation to diet energy expenditure and body composition: the PROOF study. METABOLISM-CLINICAL AND EXPERIMENTAL. 83:1-10.Full Text via DOI: 10.1016/j.metabol.2018.01.019 PMID: 29374510
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2018Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. CELL METABOLISM. 27:805-+.Full Text via DOI: 10.1016/j.cmet.2018.02.019 PMID: 29576535
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2018Changes in Gut Microbiota-Related Metabolites and Longterm Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. DIABETES CARE. 41:413-419.Full Text via DOI: 10.2337/dc17-2108 PMID: 29305401
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2018OneFlorida Clinical Research Consortium: Linking a Clinical and Translational Science Institute With a Community-Based Distributive Medical Education Model. ACADEMIC MEDICINE. 451-455.Full Text via DOI: 10.1097/ACM.0000000000002029 PMID: 29045273
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2018Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy. OBESITY. 26:332-339.Full Text via DOI: 10.1002/oby.22094 PMID: 29363287
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2018Plasma Amino Acids During 8 Weeks of Overfeeding: Relation to Diet Body Composition and Fat Cell Size in the PROOF Study. OBESITY. 26:324-331.Full Text via DOI: 10.1002/oby.22087 PMID: 29280309
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2017Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue. INTERNATIONAL JOURNAL OF OBESITY. 41:1646-1653.Full Text via DOI: 10.1038/ijo.2017.155 PMID: 28674442
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2017New compartment model analysis of lean-mass and fat-mass growth with overfeeding (vol 32, pg 590, 2016). NUTRITION. 122-122.Full Text via DOI: 10.1016/j.nut.2017.07.002
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2017MicroRNA-196 Regulates HOX Gene Expression in Human Gluteal Adipose Tissue. OBESITY. 25:1375-1383.Full Text via DOI: 10.1002/oby.21896 PMID: 28649807
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2017Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome. MOLECULAR METABOLISM. 6:703-714.Full Text via DOI: 10.1016/j.molmet.2017.05.001 PMID: 28702326
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2017The ratio of pericardial to subcutaneous adipose tissues is associated with insulin resistance. OBESITY. 25:1284-1291.Full Text via DOI: 10.1002/oby.21875 PMID: 28558132
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2017Coadministration of lorcaserin and phentermine for weight management: A 12-week, randomized, pilot safety study. OBESITY. 25:857-865.Full Text via DOI: 10.1002/oby.21811 PMID: 28440045
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2017Pioglitazone-induced improvements in insulin sensitivity occur without concomitant changes in muscle mitochondrial function. METABOLISM-CLINICAL AND EXPERIMENTAL. 69:24-32.Full Text via DOI: 10.1016/j.metabol.2016.11.016 PMID: 28285649
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2017Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 102:111-121.Full Text via DOI: 10.1210/jc.2016-3211 PMID: 27778643
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2017Effects of 13-Hour Hyperglucagonemia on Energy Expenditure and Hepatic Glucose Production in Humans. DIABETES. 66:36-44.Full Text via DOI: 10.2337/db16-0746 PMID: 27999106
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2017Effects of Lorcaserin on Pre-Existing Valvulopathy: A Pooled Analysis of Phase 3 Trials. OBESITY. 25:39-44.Full Text via DOI: 10.1002/oby.21695 PMID: 27888609
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2016Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:25306-25318.Full Text via DOI: 10.1074/jbc.M116.749424 PMID: 27738103
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2016Active Individuals have High Mitochondrial Content and Oxidative Markers in Their Abdominal Subcutaneous Adipose Tissue. OBESITY. 24:2467-2470.Full Text via DOI: 10.1002/oby.21669 PMID: 27804230
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2016Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 101:4994-5003.Full Text via DOI: 10.1210/jc.2016-2742 PMID: 27710240
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2016Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial. DIABETES CARE. 39:1909-1914.Full Text via DOI: 10.2337/dc16-1111 PMID: 27581055
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2016Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial. INTERNATIONAL JOURNAL OF OBESITY. 40:1723-1729.Full Text via DOI: 10.1038/ijo.2016.128 PMID: 27460602
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2016Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113:E6418-E6426.Full Text via DOI: 10.1073/pnas.1614467113 PMID: 27708159
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2016No Evidence for Metabolic Adaptation in Thermic Effect of Food by Dietary Protein. OBESITY. 24:1639-1642.Full Text via DOI: 10.1002/oby.21541 PMID: 27356102
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2016The OneFlorida data trust: Achieving health equity through research & training capacity building. IMPLEMENTATION SCIENCE.
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2016Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity. JOURNAL OF LIPID RESEARCH. 57:1256-1263.Full Text via DOI: 10.1194/jlr.M067728 PMID: 27178044
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2016A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity (vol 70, pg 1097, 2015). JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 839-840.Full Text via DOI: 10.1093/gerona/glw056
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2016Growth Hormone Receptor Expression in Human Gluteal Versus Abdominal Subcutaneous Adipose Tissue: Association with Body Shape. OBESITY. 24:1090-1096.Full Text via DOI: 10.1002/oby.21460 PMID: 27015877
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2016Effect of Naltrexone-Bupropion on Major Adverse Cardiovascular Events in Overweight and Obese Patients With Cardiovascular Risk Factors A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 315:990-1004.Full Text via DOI: 10.1001/jama.2016.1558 PMID: 26954408
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2016Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial. AGING CELL. 15:22-27.Full Text via DOI: 10.1111/acel.12400 PMID: 26443692
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2016Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. JOURNAL OF BONE AND MINERAL RESEARCH. 31:40-51.Full Text via DOI: 10.1002/jbmr.2701 PMID: 26332798
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2015Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes. DIABETES. 64:4033-4045.Full Text via DOI: 10.2337/db15-0305 PMID: 26253614
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2015Effect of Serial Cell Passaging in the Retention of Fiber Type and Mitochondrial Content in Primary Human Myotubes. OBESITY. 23:2414-2420.Full Text via DOI: 10.1002/oby.21192 PMID: 26538189
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2015Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery. DIABETES. 64:3737-3750.Full Text via DOI: 10.2337/db15-0809 PMID: 26293505
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2015Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. INTERNATIONAL JOURNAL OF OBESITY. 39:1607-1618.Full Text via DOI: 10.1038/ijo.2015.104 PMID: 26041698
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2015Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 100:3683-3692.Full Text via DOI: 10.1210/JC.2014-4125 PMID: 26171795
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2015A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 70:1097-1104.Full Text via DOI: 10.1093/gerona/glv057 PMID: 26187233
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2015A transcriptional signature of "exercise resistance" in skeletal muscle of individuals with type 2 diabetes mellitus. METABOLISM-CLINICAL AND EXPERIMENTAL. 64:999-1004.Full Text via DOI: 10.1016/j.metabol.2015.06.008 PMID: 26163877
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2015Adaptation of -Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance. DIABETES. 64:2550-2559.Full Text via DOI: 10.2337/db15-0106 PMID: 25754957
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2015Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium. DIABETES. 64:2299-2309.Full Text via DOI: 10.2337/db15-0004 PMID: 26106187
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2015COMBINATION WEIGHT MANAGEMENT PHARMACOTHERAPY WITH LORCASERIN AND IMMEDIATE RELEASE PHENTERMINE. JOURNAL OF GENERAL INTERNAL MEDICINE. S124-S124.
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2015Effect of protein overfeeding on energy expenditure measured in a metabolic chamber. AMERICAN JOURNAL OF CLINICAL NUTRITION. 101:496-505.Full Text via DOI: 10.3945/ajcn.114.091769 PMID: 25733634
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2015Adipokine Zinc-alpha 2-Glycoprotein Regulated by Growth Hormone and Linked to Insulin Sensitivity. OBESITY. 23:322-328.Full Text via DOI: 10.1002/oby.20856 PMID: 25098857
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2014Early Weight Loss While on Lorcaserin, Diet and Exercise as a Predictor of Week 52 Weight-Loss Outcomes. OBESITY. 22:2137-2146.Full Text via DOI: 10.1002/oby.20841 PMID: 25044799
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2014Safety and Efficacy of Lorcaserin: A Combined Analysis of the BLOOM and BLOSSOM Trials. POSTGRADUATE MEDICINE. 126:7-18.Full Text via DOI: 10.3810/pgm.2014.10.2817 PMID: 25414931
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2014A Macrophage NBR1-MEKK3 Complex Triggers JNK-Mediated Adipose Tissue Inflammation in Obesity. CELL METABOLISM. 20:499-511.Full Text via DOI: 10.1016/j.cmet.2014.06.008 PMID: 25043814
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2014Drug Treatment of Obesity. JAMA INTERNAL MEDICINE. 1414-1415.PMID: 25090179
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2014Identification of a Novel lncRNA in Gluteal Adipose Tissue and Evidence for Its Positive Effect on Preadipocyte Differentiation. OBESITY. 22:1781-1785.Full Text via DOI: 10.1002/oby.20793 PMID: 24862299
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2014Commonality versus specificity among adiposity traits in normal-weight and moderately overweight adults. INTERNATIONAL JOURNAL OF OBESITY. 38:719-723.Full Text via DOI: 10.1038/ijo.2013.153 PMID: 23949614
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2014Interaction between dietary fat and exercise on excess postexercise oxygen consumption. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 306:E1093-E1098.Full Text via DOI: 10.1152/ajpendo.00383.2013 PMID: 24644241
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2014Determinants of sedentary 24-h energy expenditure: equations for energy prescription and adjustment in a respiratory chamber. AMERICAN JOURNAL OF CLINICAL NUTRITION. 99:834-842.Full Text via DOI: 10.3945/ajcn.113.079566 PMID: 24500151
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2014Changes in Insulin Sensitivity and Insulin Secretion with the Sodium Glucose Cotransporter 2 Inhibitor Dapagliflozin. DIABETES TECHNOLOGY & THERAPEUTICS. 16:137-144.Full Text via DOI: 10.1089/dia.2013.0167 PMID: 24237386
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2014Effect of Prolonged Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-obese Younger Adults.. JOURNAL OF BONE AND MINERAL RESEARCH. S70-S71.
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2014Lipid in Skeletal Muscle Myotubes Is Associated to the Donors' Insulin Sensitivity and Physical Activity Phenotypes. OBESITY. 22:426-434.Full Text via DOI: 10.1002/oby.20556 PMID: 23818429
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2013Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial. DIABETES OBESITY & METABOLISM. 15:931-937.Full Text via DOI: 10.1111/dom.12099 PMID: 23551856
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2013The Effect of Leptin, Caffeine/Ephedrine and their Combination Upon Visceral Fat Mass and Weight Loss. OBESITY. 21:1991-1996.Full Text via DOI: 10.1002/oby.20416 PMID: 23686786
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2013Combination therapy with naltrexone and bupropion for obesity reduces total and visceral adiposity. DIABETES OBESITY & METABOLISM. 15:863-866.Full Text via DOI: 10.1111/dom.12095 PMID: 23489381
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2013Echocardiographic Assessment of Cardiac Valvular Regurgitation With Lorcaserin From Analysis of 3 Phase 3 Clinical Trials. CIRCULATION-CARDIOVASCULAR IMAGING. 6:560-567.Full Text via DOI: 10.1161/CIRCIMAGING.112.000128 PMID: 23661689
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2013Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. JOURNAL OF CLINICAL INVESTIGATION. 123:2564-2575.Full Text via DOI: 10.1172/JCI67652 PMID: 23676496
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2013Imbalance between Neutrophil Elastase and its Inhibitor alpha(1)-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure. CELL METABOLISM. 17:534-548.Full Text via DOI: 10.1016/j.cmet.2013.03.005 PMID: 23562077
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2013Nine Months of Combined Training Improves Ex Vivo Skeletal Muscle Metabolism in Individuals With Type 2 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 98:1694-1702.Full Text via DOI: 10.1210/jc.2012-3874 PMID: 23463651
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2013Integrating muscle cell biochemistry and whole-body physiology in humans: P-31-MRS data from the InSight trial. SCIENTIFIC REPORTS. 3.Full Text via DOI: 10.1038/srep01182 PMID: 23378914
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2013Distinct Developmental Signatures of Human Abdominal and Gluteal Subcutaneous Adipose Tissue Depots. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 98:362-371.Full Text via DOI: 10.1210/jc.2012-2953 PMID: 23150689
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2013The role of osteocalcin in human glucose metabolism: marker or mediator?. NATURE REVIEWS ENDOCRINOLOGY. 43-55.Full Text via DOI: 10.1038/nrendo.2012.201 PMID: 23147574
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2012Sarcopenic obesity: A Critical appraisal of the current evidence. CLINICAL NUTRITION. 583-601.Full Text via DOI: 10.1016/j.clnu.2012.06.010 PMID: 22809635
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2012Randomized Placebo-Controlled Clinical Trial of Lorcaserin for Weight Loss in Type 2 Diabetes Mellitus: The BLOOM-DM Study. OBESITY. 20:1426-1436.Full Text via DOI: 10.1038/oby.2012.66 PMID: 22421927
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2012Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. JOURNAL OF LIPID RESEARCH. 53:839-848.Full Text via DOI: 10.1194/jlr.M019182 PMID: 22383684
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2012Dietary Protein and Weight Gain Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 1692-1692.Full Text via DOI: 10.1001/jama.2012.533
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2012Does Rimonabant Independently Affect Free Fatty Acid and Glucose Metabolism?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 97:819-827.Full Text via DOI: 10.1210/jc.2011-2486 PMID: 22170727
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2012Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating A Randomized Controlled Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 307:47-55.Full Text via DOI: 10.1001/jama.2011.1918 PMID: 22215165
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2012Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 97:242-250.Full Text via DOI: 10.1210/jc.2011-1798 PMID: 22049170
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2012Obesity Therapy. ATLAS OF DIABETES, FOURTH EDITION. 313-337.Full Text via DOI: 10.1007/978-1-4614-1028-7_15
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2011Reduced Coupling of Oxidative Phosphorylation In Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice. PLOS ONE. 6.Full Text via DOI: 10.1371/journal.pone.0026963 PMID: 22132085
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2011A One-Year Randomized Trial of Lorcaserin for Weight Loss in Obese and Overweight Adults: The BLOSSOM Trial. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:3067-3077.Full Text via DOI: 10.1210/jc.2011-1256 PMID: 21795446
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2011Does rimonabant independently affect NEFA and glucose metabolism?. DIABETOLOGIA. S270-S270.
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2011Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans. DIABETES. 60:1734-1742.Full Text via DOI: 10.2337/db10-1364 PMID: 21498783
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2011Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:1654-1663.Full Text via DOI: 10.1210/jc.2011-0585 PMID: 21602457
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2011Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?. DIABETES CARE. 34:1424-1430.Full Text via DOI: 10.2337/dc11-0447 PMID: 21602431
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2011Naltrexone-buproprion causes weight loss in overweight and obese adults.. Evidence-based medicine. 53-4.Full Text via DOI: 10.1136/ebm1167 PMID: 21228058
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2011Skeletal Muscle Mitochondrial Capacity and Insulin Resistance in Type 2 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:1160-1168.Full Text via DOI: 10.1210/jc.2010-1621 PMID: 21307136
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2011Lorcaserin, A 5-HT2C Receptor Agonist, Reduces Body Weight by Decreasing Energy Intake without Influencing Energy Expenditure. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:837-845.Full Text via DOI: 10.1210/jc.2010-1848 PMID: 21190985
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2011miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor gamma Expression. MOLECULAR AND CELLULAR BIOLOGY. 31:626-638.Full Text via DOI: 10.1128/MCB.00894-10 PMID: 21135128
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2011Beta-cell preservationIs weight loss the answer?. The review of diabetic studies : RDS. 446-53.Full Text via DOI: 10.1900/RDS.2011.8.446 PMID: 22580726
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2011Isolation and Growth of Stem Cells. TISSUE ENGINEERING: FROM LAB TO CLINIC. 93-111.Full Text via DOI: 10.1007/978-3-642-02824-3_6
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2010Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management.. NEW ENGLAND JOURNAL OF MEDICINE. 363:245-256.PMID: 20647200
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2009A Look at the Low-Carbohydrate Diet. NEW ENGLAND JOURNAL OF MEDICINE. 2286-2288.PMID: 19955530
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2009Natriuretic Peptides: New Players in Energy Homeostasis. DIABETES. 2726-2728.Full Text via DOI: 10.2337/db09-1335 PMID: 19940236
Research
principal investigator on
Background
Full Name
- Steven R Smith, MD