Adipokine Zinc-alpha 2-Glycoprotein Regulated by Growth Hormone and Linked to Insulin Sensitivity Article

International Collaboration

cited authors

  • Balaz, Miroslav, Ukropcova, Barbara, Kurdiova, Timea, Gajdosechova, Lucia, Vlcek, Miroslav, Janakova, Zuzana, Fedeles, Jozef, Pura, Mikulas, Gasperikova, Daniela, Smith, Steven R., Tkacova, Ruzena, Klimes, Iwar, Payer, Juraj, Wolfrum, Christian, Ukropec, Jozef

funding text

  • This work was supported by Pfizer Global Investigator Initiated Research Grant, EFSD New Horizons, Slovak Research and Development Agency Grant 0122-06, Scientific Grant Agency of the Slovak Academy of Sciences grants # 2/0198/11 & 2/0174/12, and National Scholarship Programme of the Slovak Republic.

abstract

  • ObjectiveHypertrophic obesity is associated with impaired insulin sensitivity and lipid-mobilizing activity of zinc-2-glycoprotein. Adipose tissue (AT) of growth hormone (GH) -deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothesized that zinc-2-glycoprotein is regulated by GH and mediates some of its beneficial effects in AT. MethodsAT from patients with GH deficiency and individuals with obesity-related GH deficit was obtained before and after 5-year and 24-month GH supplementation therapy. GH action was tested in primary human adipocytes. Relationships of GH and zinc-2-glycoprotein with adipocyte size and insulin sensitivity were evaluated in nondiabetic patients with noncancerous cachexia and hypertrophic obesity. ResultsAT in GH-deficient adults displayed a substantial reduction of zinc-2-glycoprotein. GH therapy normalized AT zinc-2-glycoprotein. Obesity-related relative GH deficit was associated with almost 80% reduction of zinc-2-glycoprotein mRNA in AT. GH increased zinc-2-glycoprotein mRNA in both AT of obese men and primary human adipocytes. Interdependence of GH and zinc-2-glycoprotein in regulating AT morphology and metabolic phenotype was evident from their relationship with adipocyte size and AT-specific and whole-body insulin sensitivity. ConclusionsThe results demonstrate that GH is involved in regulation of AT zinc-2-glycoprotein; however, the molecular mechanism linking GH and zinc-2-glycoprotein in AT is yet unknown.

authors

Publication Date

  • February 1, 2015

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published in

category

start page

  • 322

end page

  • 328

volume

  • 23

issue

  • 2

WoS Citations

  • 3

WoS References

  • 40