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Nunez-Lopez, Yury O., PhD
Overview
overview
- Over 25 years of valuable wet lab and bioinformatic experiences. Implemented and managed the entire research workflow, from developing research ideas and writing grant proposals to designing and performing experimental procedures, conducting high throughput data analyses, and publishing results in peer reviewed journals. Established the NGS section of a Cancer Pharmacogenomics laboratory from scratch: handled the research and negotiation process to purchase NGS instrument, conducted site preparation for installation, designed and implemented pipelines for data generation using commercial software and in-house developed R scripts. Contributed advanced understandings of biological principles underlying gene and microRNA regulation, cellular pathway analysis, comparative genomics, gene coexpression networks, and statistical modeling, among others. Currently studying metabolism, obesity, diabetes, cancer, and aging. Involved in translational research in the extracellular vesicle field. Expertise in microRNA profiling, transcriptomics, and proteomics.
research areas
Affiliation
Member of
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Research Department
Publications
Most Recent Publications
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2023The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes. FRONTIERS IN ENDOCRINOLOGY. 14.Full Text via DOI: 10.3389/fendo.2023.1219293 PMID: 37576973
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2023Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. DIABETES RESEARCH AND CLINICAL PRACTICE. 197.Full Text via DOI: 10.1016/j.diabres.2023.110565 PMID: 36736734
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2023Detectable Lipidomes and Metabolomes by Different Plasma Exosome Isolation Methods in Healthy Controls and Patients with Advanced Prostate and Lung Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24.Full Text via DOI: 10.3390/ijms24031830 PMID: 36768152
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2022A comparative Proteomics Analysis Identified Differentially Expressed Proteins in Pancreatic Cancer-Associated Stellate Cell Small Extracellular Vesicles. MOLECULAR & CELLULAR PROTEOMICS. 21.Full Text via DOI: 10.1016/j.mcpro.2022.100438 PMID: 36332889
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2022Coordinated regulation of gene expression and microRNA changes in adipose tissue and circulating extracellular vesicles in response to pioglitazone treatment in humans with type 2 diabetes. FRONTIERS IN ENDOCRINOLOGY. 13.Full Text via DOI: 10.3389/fendo.2022.955593 PMID: 36120427
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2022Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23.Full Text via DOI: 10.3390/ijms23105779 PMID: 35628588
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2022Plasma miRNA Profile of Crohn's Disease and Rheumatoid Arthritis Patients. BIOLOGY-BASEL. 11.Full Text via DOI: 10.3390/biology11040508 PMID: 35453708
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2021Circulating microRNA profile in humans and mice with congenital GH deficiency. AGING CELL.Full Text via DOI: 10.1111/acel.13420 PMID: 34118183
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2021Investigation of Extracellular Vesicles From SARS-CoV-2 Infected Specimens: A Safety Perspective. FRONTIERS IN IMMUNOLOGY. 12.Full Text via DOI: 10.3389/fimmu.2021.617042 PMID: 33968019
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2019Profiling of tRNA Halves and YRNA Fragments in Serum and Tissue From Oral Squamous Cell Carcinoma Patients Identify Key Role of 5 ' tRNA-Val-CAC-2-1 Half. FRONTIERS IN ONCOLOGY. 9.Full Text via DOI: 10.3389/fonc.2019.00959 PMID: 31616639
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2019Predicting and understanding the response to short-term intensive insulin therapy in people with early type 2 diabetes. MOLECULAR METABOLISM. 20:63-78.Full Text via DOI: 10.1016/j.molmet.2018.11.003 PMID: 30503831
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2018Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. EXPERIMENTAL GERONTOLOGY. 108:35-40.Full Text via DOI: 10.1016/j.exger.2018.03.012 PMID: 29596868
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2018Blood Serum From Head and Neck Squamous Cell Carcinoma Patients Induces Altered MicroRNA and Target Gene Expression Profile in Treated Cells. FRONTIERS IN ONCOLOGY. 8.Full Text via DOI: 10.3389/fonc.2018.00217 PMID: 29942793
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2018Tissue and serum microRNA profile of oral squamous cell carcinoma patients. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-017-18945-z PMID: 29330429
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2018Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes. REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY. 23:6-20.Full Text via DOI: 10.1016/j.rpot.2017.10.003 PMID: 29187807
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2018Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.Full Text via DOI: 10.1155/2018/7351902 PMID: 29721017
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2017MicroRNAs and the metabolic hallmarks of aging. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 455:131-147.Full Text via DOI: 10.1016/j.mce.2016.12.021 PMID: 28062199
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2017Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 49:117-122.Full Text via DOI: 10.1016/j.jnutbio.2017.08.007 PMID: 28945992
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2017Persistent Differences in MicroRNAs Responsive to Bariatric Surgery. AMERICAN JOURNAL OF GASTROENTEROLOGY. S588-S588.
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2017Gastric bypass surgery with exercise alters plasma microRNAs that predict improvements in cardiometabolic risk. INTERNATIONAL JOURNAL OF OBESITY. 41:1121-1130.Full Text via DOI: 10.1038/ijo.2017.84 PMID: 28344345
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2017Reduced Skeletal Muscle Secreted Frizzled-Related Protein 3 is Associated with Inflammation and Insulin Resistance. OBESITY. 25:697-703.Full Text via DOI: 10.1002/oby.21787 PMID: 28240822
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2017Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. MOLECULAR BIOSYSTEMS. 13:106-121.Full Text via DOI: 10.1039/c6mb00596a PMID: 27869909
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2016Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study. SCIENTIFIC REPORTS. 6.Full Text via DOI: 10.1038/srep31479 PMID: 27558530
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2015Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse. AGING CELL. 14:1055-1066.Full Text via DOI: 10.1111/acel.12373 PMID: 26176567
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2015Circulating small non coding RNA signature in head and neck squamous cell carcinoma. ONCOTARGET. 6:19246-19263.PMID: 26057471
Background
Full Name
- Yury O. Nunez-Lopez, PhD
Education
- Institute of Nuclear Sciences & Technology, Cuba
Residency
- Yale University School of Medicine, Research Associate
Fellowship
- Rutgers University, NJ
Contact
primary email
- Research.Institute@AdventHealth.com