Litherland, Sally A, PhD, MS, MS

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Litherland, Sally A, PhD, MS, MS
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Most Recent Publications

2022

Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. JOURNAL OF MEDICINAL CHEMISTRY.
Full Text via DOI: 10.1021/acs.jmedchem.2c01350 PMID: 36382923
2022

Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation.. PLOS ONE. e0265725.
Full Text via DOI: 10.1371/journal.pone.0265725 PMID: 35316296
2021

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. ACS CHEMICAL NEUROSCIENCE. 12:542-556.
Full Text via DOI: 10.1021/acschemneuro.0c00755 PMID: 33470098
2020

Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. CELL COMMUNICATION AND SIGNALING. 18.
Full Text via DOI: 10.1186/s12964-020-00594-x PMID: 32552827
2019

K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas. EPIGENETICS INSIGHTS. 12.
Full Text via DOI: 10.1177/2516865719828348 PMID: 30815628
2018

Targeting lysophospholipid metabolism inhibits pancreatic cancer cell proliferation under nutrient-limiting conditions. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2018-2916
2018

Portal Vein Circulating Tumor Cells (CTC) Conform Multi-Cellular Type Clusters in Patients with Peri-Ampullary Carcinomas. ANNALS OF SURGICAL ONCOLOGY. S122-S122.
2018

Pancreatic and bile duct cancer circulating tumor cells (CTC) form immune-resistant multi-cell type clusters in the portal venous circulation. CANCER BIOLOGY & THERAPY. 19:887-897.
Full Text via DOI: 10.1080/15384047.2018.1480292 PMID: 30067440
2017

Portal Venous Blood Circulation Supports Immunosuppressive Environment and Pancreatic Cancer Circulating Tumor Cell Activation. PANCREAS. 46:116-123.
Full Text via DOI: 10.1097/MPA.0000000000000667 PMID: 27400259
2016

Blatchford Score Is Superior to AIMS65 Score in Predicting the Need for Clinical Interventions in Elderly Patients with Nonvariceal Upper Gastrointestinal Bleed.. Advances in medicine. 6850754.
Full Text via DOI: 10.1155/2016/6850754 PMID: 27648468
2015

Assay Development for detection of estrogen responsive gene histone acetylation in breast cancer circulating tumor cells. CANCER RESEARCH.
2015

Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetesprone Bicongenic B6. NODC11bxC1tb Mice. GENETICS & EPIGENETICS. 7:5-17.
Full Text via DOI: 10.4137/GEG.S29696 PMID: 26512207
2014

Ethnicity Disparities of Breast Cancer within an Insured Population. BREAST JOURNAL. 331-332.
Full Text via DOI: 10.1111/tbj.12271 PMID: 24750514
2013

Ethnicity disparities of breast cancer in an insured population. CANCER RESEARCH.
Full Text via DOI: 10.1158/0008-5472.SABCS13-P5-12-04
2013

Persistent STAT5 Phosphorylation and Epigenetic Dysregulation of GM-CSF and PGS2/COX2 Expression in Type 1 Diabetic Human Monocytes. PLOS ONE. 8.
Full Text via DOI: 10.1371/journal.pone.0076919 PMID: 24204704
2012

Developing a nanoparticle test for prostate cancer scoring. JOURNAL OF TRANSLATIONAL MEDICINE. 10.
Full Text via DOI: 10.1186/1479-5876-10-44 PMID: 22404986
2012

In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation. AMERICAN JOURNAL OF STEM CELLS. 1:114-127.
PMID: 22833839
2010

Pharmacological Characterization of 30 Human Melanocortin-4 Receptor Polymorphisms with the Endogenous Proopiomelanocortin-Derived Agonists, Synthetic Agonists, and the Endogenous Agouti-Related Protein Antagonist. BIOCHEMISTRY. 49:4583-4600.
Full Text via DOI: 10.1021/bi100068u PMID: 20462274
2009

Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. FASEB JOURNAL. 23:642-655.
Full Text via DOI: 10.1096/fj.08-109686 PMID: 18971258
2009

Construction and Characterization of Melanocortin-2 and-4 Receptor Chimeras. PEPTIDES FOR YOUTH. 611:301-302.
Full Text via DOI: 10.1007/978-0-387-73657-0_135 PMID: 19400202
2009

Discovery of a Ligand that Compensates for Decreased Endogenous Agonist Potency of Melanocortin-4 Receptor Polymorphisms Identified in Obese Humans. PEPTIDES FOR YOUTH. 611:509-510.
Full Text via DOI: 10.1007/978-0-387-73657-0_221 PMID: 19400288
2008

GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells. JOURNAL OF AUTOIMMUNITY. 31:377-384.
Full Text via DOI: 10.1016/j.jaut.2008.08.010 PMID: 18945591
2008

Immunopathogenic Interaction of Environmental Triggers and Genetic Susceptibility in Diabetes Is Epigenetics the Missing Link?. DIABETES. 3184-3186.
Full Text via DOI: 10.2337/db08-1275 PMID: 19033405
2008

M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice. CLINICAL & DEVELOPMENTAL IMMUNOLOGY.
Full Text via DOI: 10.1155/2008/769795 PMID: 19165346
2007

Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms. BIOCHEMISTRY. 46:8273-8287.
Full Text via DOI: 10.1021/bi7007382 PMID: 17590021
2007

Truncated pStat5B is associated with the Idd4 locus in NOD mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 356:655-661.
Full Text via DOI: 10.1016/j.bbrc.2007.03.028 PMID: 17382905
2007

Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. TISSUE ANTIGENS. 69:181-188.
Full Text via DOI: 10.1111/j.1399-0039.2006.00730.x PMID: 17257322
2006

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the Agouti-related protein (AGRP) antagonist. BIOCHEMISTRY. 45:7277-7288.
Full Text via DOI: 10.1021/bi0600300 PMID: 16752916
2006

Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism. CHEMICAL BIOLOGY & DRUG DESIGN. 67:215-229.
Full Text via DOI: 10.1111/j.1747-0285.2006.00362.x PMID: 16611215
2006

Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent - Implications for the NOD STAT5B mutation in diabetes pathogenesis. IMMUNOLOGY OF DIABETES IV: PROGRESS IN OUR UNDERSTANDING. 1079:198-204.
Full Text via DOI: 10.1196/annals.1375.031 PMID: 17130555
2005

Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction. JOURNAL OF IMMUNOLOGY. 175:4561-4565.
PMID: 16177100
2005

Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages. JOURNAL OF AUTOIMMUNITY. 24:297-310.
Full Text via DOI: 10.1016/j.jaut.2005.02.001 PMID: 15927792
2004

Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles. ANALYTICAL BIOCHEMISTRY. 334:135-144.
Full Text via DOI: 10.1016/j.ab.2004.08.005 PMID: 15464962
2004

In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. DIABETES. 53:1721-1732.
PMID: 15220196
2004

IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes. JOURNAL OF AUTOIMMUNITY. 22:227-233.
Full Text via DOI: 10.1016/j.jaut.2003.12.006 PMID: 15041043
2003

CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar typhimurium infection. INFECTION AND IMMUNITY. 71:6582-6590.
Full Text via DOI: 10.1128/IAI.71.11.6582-6590.2003 PMID: 14573680
2003

Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.. PEDIATRIC DIABETES. 10-8.
PMID: 14655518
2003

Abnormal peripheral blood dendritic cell populations in type 1 diabetes. IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN. 1005:222-225.
Full Text via DOI: 10.1196/annals.1288.031 PMID: 14679064
1999

Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. JOURNAL OF CLINICAL INVESTIGATION. 104:515-523.
PMID: 10449443

Full Name

Sally A Litherland, PhD