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Coen, Paul M, PhD
Overview
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- Dr. Paul Coen is an Associate Investigator at the Translational Research Institute, AdventHealth Orlando. Paul’s research program is supported by the National Institutes of Health (NIH) and is broadly focused on elucidating the role of skeletal muscle mitochondrial energetics in the pathophysiology’s associated with aging and obesity. Paul’s postdoctoral training was in the area of muscle metabolism under the mentorship of Dr. Bret Goodpaster at the University of Pittsburgh’s Division of Endocrinology and Metabolism (2008-2010). His postdoctoral work resulted in authorship on numerous peer-reviewed publications in high impact journals such as the Journal of Clinical Investigation, Diabetes, and Diabetes Care. Originally hailing from Dublin, Ireland, Paul made the jump across the pond to study for a PhD in Exercise Physiology at Purdue University, which he completed in 2008. Prior to this, he completed an M.S. in Vascular Biology at the Vascular Health Research Center (VHRC) at Dublin City University (2004), and received his initial didactic and laboratory-based training with a B.Sc. in Bioanalytical Science from the Institute of Technology, Tallaght, Ireland (2000).
Affiliation
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Publications
Most Recent Publications
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2024Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. FREE RADICAL BIOLOGY AND MEDICINE. 223:384-397.Full Text via DOI: 10.1016/j.freeradbiomed.2024.07.039 PMID: 39097206
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2024Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA). JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae187 PMID: 39066507
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2024Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis. ARTHRITIS & RHEUMATOLOGY.Full Text via DOI: 10.1002/art.42953 PMID: 39016102
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2024Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). JOURNAL OF SPORT AND HEALTH SCIENCE. 13:621-630.Full Text via DOI: 10.1016/j.jshs.2024.02.001 PMID: 38341136
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2024Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae101 PMID: 38605684
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2024The mitochondrial multi-omic response to exercise training across rat tissues. CELL METABOLISM. 36.Full Text via DOI: 10.1016/j.cmet.2023.12.021 PMID: 38701776
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2024Higher expression of denervation-responsive genes is negatively associated with muscle volume and performance traits in the study of muscle, mobility, and aging (SOMMA). AGING CELL. 23.Full Text via DOI: 10.1111/acel.14115 PMID: 38831622
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2024Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. OBESITY. 32:1125-1135.Full Text via DOI: 10.1002/oby.24008 PMID: 38803308
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2024Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA). JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae049 PMID: 38416053
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2024Associations Between D3Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae056 PMID: 38367212
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2024Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae047 PMID: 38366047
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2024Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glad283 PMID: 38150179
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2024The Association of Skeletal Muscle Energetics With Recurrent Falls in Older Adults Within the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae018 PMID: 38206375
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2024Childhood adverse life events and skeletal muscle mitochondrial function. SCIENCE ADVANCES. 10.Full Text via DOI: 10.1126/sciadv.adj6411 PMID: 38446898
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2024The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA). AGING CELL.Full Text via DOI: 10.1111/acel.14129 PMID: 38429931
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2024Chronic exercise improves hepatic acylcarnitine handling. ISCIENCE. 27.Full Text via DOI: 10.1016/j.isci.2024.109083 PMID: 38361627
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2024Energetics and clinical factors for the time required to walk 400 m: The Study of Muscle, Mobility and Aging (SOMMA). JOURNAL OF THE AMERICAN GERIATRICS SOCIETY.Full Text via DOI: 10.1111/jgs.18763 PMID: 38243364
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2023Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY.Full Text via DOI: 10.1111/jgs.18713 PMID: 38149438
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2023ASSOCIATION OF DIABETES WITH BODY COMPOSITION, CARDIORESPIRATORY FITNESS, AND MITOCHONDRIAL ENERGETICS. INNOVATION IN AGING. 640-640.
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2023DECONSTRUCTING MULTIMORBIDITY AND MUSCLE MITOCHONDRIAL RESPIRATION AND ENERGETICS IN OLDER ADULTS. INNOVATION IN AGING. 640-640.
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2023Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging. GEROSCIENCE.Full Text via DOI: 10.1007/s11357-023-01002-1 PMID: 37987886
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2023Vigor to Frailty As a Continuum-A New Approach in the Study of Muscle, Mobility, and Aging Cohort. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glad244 PMID: 37847228
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2023Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging. AGING CELL.Full Text via DOI: 10.1111/acel.14015 PMID: 37843879
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2023The multi-tissue benefits of exercise on aging human physiology. EXPERIMENTAL GERONTOLOGY.Full Text via DOI: 10.1016/j.exger.2023.112304 PMID: 37821321
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2023Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight. NPJ MICROGRAVITY. 9.Full Text via DOI: 10.1038/s41526-023-00322-y PMID: 37714852
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2023Mitochondrial Energeticsand Performance Fatigability In Older Adults: Study Of Muscle, Mobility, And Aging (SOMMA). MEDICINE & SCIENCE IN SPORTS & EXERCISE. 166-166.
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2023Reduced Muscle Energetics And Fitness In Older Adults With Diabetes Independent Of Adiposity And Activity. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 166-166.
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2023Walking Energetics, Fatigability, And Mobility In Older Adults: Study Of Muscle, Mobility, And Aging (SOMMA). MEDICINE & SCIENCE IN SPORTS & EXERCISE. 164-165.
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2023Lower mitochondrial respiration does not lead to decreased fat oxidation in young African American women without obesity. OBESITY. 31:1338-1346.Full Text via DOI: 10.1002/oby.23716 PMID: 37140394
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2023Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans. CELL REPORTS. 42.Full Text via DOI: 10.1016/j.celrep.2023.112218 PMID: 36897780
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2023Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults. JOURNAL OF PHYSIOLOGY-LONDON.Full Text via DOI: 10.1113/JP284142 PMID: 36814134
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2023The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glad052 PMID: 36754371
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2022Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glac238 PMID: 36462195
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2022AGE, PHYSICAL ACTIVITY AND MITOCHONDRIAL FUNCTION IN THE STUDY OF MUSCLE MOBILITY AND AGING (SOMMA). INNOVATION IN AGING. 863-864.
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2022ASSOCIATION BETWEEN AEROBIC CAPACITY AND PERCEIVED FATIGABILITY: THE STUDY OF MUSCLE, MOBILITY, AND AGING (SOMMA). INNOVATION IN AGING. 368-369.
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2022INTRODUCTION TO SOMMA: CONCEPTUAL CONSTRUCT AND PARTICIPANT CHARACTERISTICS. INNOVATION IN AGING. 208-208.
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2022PREDICTORS OF 400M WALKING TIME: THE STUDY OF MUSCLE MOBILITY AND AGING (SOMMA). INNOVATION IN AGING. 839-839.
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2022PRELIMINARY SOMMA DATA: COGNITIVE AND PHYSICAL FUNCTION RELATIONSHIPS IN OLDER ADULTS. INNOVATION IN AGING. 209-209.
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2022PRELIMINARY SOMMA DATA: D3CR MUSCLE MASS AND STRENGTH AND WALKING SPEED IN OLDER MEN AND WOMEN. INNOVATION IN AGING. 209-209.
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2022PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS. INNOVATION IN AGING. 209-209.
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2022RECRUITMENT OF SOMMA PARTICIPANTS: TECHNIQUES TO ENROLL OLDER ADULTS IN A COMPLEX STUDY. INNOVATION IN AGING. 208-209.
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2022SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS. INNOVATION IN AGING. 808-808.
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2022Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells. AGING CELL.Full Text via DOI: 10.1111/acel.13650 PMID: 35653714
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2022A New Approach to Understanding Cancer-Related Fatigue: Leveraging the 3P Model to Facilitate Risk Prediction and Clinical Care. CANCERS.Full Text via DOI: 10.3390/cancers14081982 PMID: 35454890
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2022NAD(+) and human muscle health. NATURE AGING. 195-196.Full Text via DOI: 10.1038/s43587-022-00192-1 PMID: 37118373
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2022Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 322:E260-E277.Full Text via DOI: 10.1152/ajpendo.00378.2021 PMID: 35068187
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2022State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.. Comprehensive Physiology. 3193-3279.Full Text via DOI: 10.1002/cphy.c200033 PMID: 35578962
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2021Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glab240 PMID: 34406407
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2021A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. CIRCULATION. 143:145-159.Full Text via DOI: 10.1161/CIRCULATIONAHA.120.049813 PMID: 33106031
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2021ASSESSING MITOCHONDRIAL ENERGETICS OF SKELETAL MUSCLE IN THE STUDY OF MUSCLE MOBILITY AND AGING (SOMMA). INNOVATION IN AGING. 125-125.
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2021ASSOCIATIONS OF BODY COMPOSITION AND MITOCHONDRIAL FUNCTION IN OLDER ADULTS. INNOVATION IN AGING. 125-126.
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2021INITIAL RESULTS FROM SOMMA: CONTRIBUTION OF MITOCHONDRIAL FUNCTION TO WALKING AND FITNESS. INNOVATION IN AGING. 124-125.
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2021MUSCLE BIOENERGETICS AND COGNITIVE EXECUTIVE FUNCTION: THE SOMMA STUDY BASELINE. INNOVATION IN AGING. 125-125.
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2021MUSCLE QUALITY REVISITED: BIOPSY ENERGETICS, MR SPECTROSCOPY, AND MUSCLE POWER AND STRENGTH. INNOVATION IN AGING. 125-125.
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2020Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 75:1744-1753.Full Text via DOI: 10.1093/gerona/glaa001 PMID: 31907525
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2020Muscle phosphorus metabolites in sarcopenia?. AGING-US. 15880-15881.PMID: 32860671
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2020Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise. FRONTIERS IN PHYSIOLOGY. 11.Full Text via DOI: 10.3389/fphys.2020.00605 PMID: 32587527
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2020Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles. AGING CELL. 19.Full Text via DOI: 10.1111/acel.13135 PMID: 32468656
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2019Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes. PHYSIOLOGICAL GENOMICS. 51:586-595.Full Text via DOI: 10.1152/physiolgenomics.00014.2019 PMID: 31588872
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2019Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 317:E899-E910.Full Text via DOI: 10.1152/ajpendo.00161.2019 PMID: 31479303
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2019Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome. SURGERY. 166:861-866.Full Text via DOI: 10.1016/j.surg.2019.04.017 PMID: 31253418
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2019Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI INSIGHT. 4.Full Text via DOI: 10.1172/jci.insight.128248 PMID: 31120438
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2019Changes On Non-exercise Physical Activity Are Related To Improvements In Mitochondrial Function Independently Of Structured Intentional Exercise. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 773-773.
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2019Mitochondria as a Target for Mitigating Sarcopenia. FRONTIERS IN PHYSIOLOGY.Full Text via DOI: 10.3389/fphys.2018.01883 PMID: 30687111
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2019A MORE DYNAMIC NAME FOR AGE-RELATED FUNCTIONAL IMPAIRMENTS. JOURNAL OF APPLIED PHYSIOLOGY. 257-257.Full Text via DOI: 10.1152/japplphysiol.00816.2018 PMID: 30694711
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2019Chronic Exercise and Immunity. LIFESTYLE MEDICINE, 3RD EDITION. 547-554.
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2019EVOLUTION OF THE DEFINITION OF SARCOPENIA. JOURNAL OF APPLIED PHYSIOLOGY. 258-258.
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2019Metabolomics Analyses of Muscle Atrophy Induced by Hind Limb Unloading. METABOLOMICS: METHODS AND PROTOCOLS. 1996:297-309.Full Text via DOI: 10.1007/978-1-4939-9488-5_22 PMID: 31127563
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2018Exercise and Bariatric Surgery: An Effective Therapeutic Strategy. EXERCISE AND SPORT SCIENCES REVIEWS. 262-270.Full Text via DOI: 10.1249/JES.0000000000000168 PMID: 30052546
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2018Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 73:1313-1322.Full Text via DOI: 10.1093/gerona/gly051 PMID: 29562317
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2018In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury. AGING CELL. 17.Full Text via DOI: 10.1111/acel.12815 PMID: 30003692
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201812,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake (vol 27, pg 1111, 2018). CELL METABOLISM. 1357-1357.Full Text via DOI: 10.1016/j.cmet.2018.04.023 PMID: 29874569
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201812,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. CELL METABOLISM. 27:1111-+.Full Text via DOI: 10.1016/j.cmet.2018.03.020 PMID: 29719226
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2018Mitochondrial Respiration is Associated with Lower Energy Expenditure and Lower Aerobic Capacity in African American Women. OBESITY. 26:903-909.Full Text via DOI: 10.1002/oby.22163 PMID: 29687648
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2018Nitrite Improves Skeletal Muscle Mitochondrial Coupling and Walking Efficiency in Older Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S6-S6.
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2018Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 9:279-294.Full Text via DOI: 10.1002/jcsm.12272 PMID: 29368427
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2018Calorie Restriction-induced Weight Loss and Exercise Have Differential Effects on Skeletal Muscle Mitochondria Despite Similar Effects on Insulin Sensitivity. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 73:81-87.Full Text via DOI: 10.1093/gerona/glw328 PMID: 28158621
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2017Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding. OBESITY. 25:2079-2087.Full Text via DOI: 10.1002/oby.21980 PMID: 29071793
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2017REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 313:E737-E747.Full Text via DOI: 10.1152/ajpendo.00120.2017 PMID: 28899858
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2017Effects of beta-hydroxy-beta-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. JOURNAL OF APPLIED PHYSIOLOGY. 123:1092-1100.Full Text via DOI: 10.1152/japplphysiol.00192.2017 PMID: 28705993
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2017Persistent Differences in MicroRNAs Responsive to Bariatric Surgery. AMERICAN JOURNAL OF GASTROENTEROLOGY. S588-S588.
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2017Gastric bypass surgery with exercise alters plasma microRNAs that predict improvements in cardiometabolic risk. INTERNATIONAL JOURNAL OF OBESITY. 41:1121-1130.Full Text via DOI: 10.1038/ijo.2017.84 PMID: 28344345
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2017Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB. OBESITY. 25:1206-1216.Full Text via DOI: 10.1002/oby.21864 PMID: 28558160
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2017Skeletal muscle PGC-1 beta signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 312:E394-E406.Full Text via DOI: 10.1152/ajpendo.00380.2016 PMID: 28270443
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2017Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 72:535-542.Full Text via DOI: 10.1093/gerona/glw102 PMID: 27325231
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2017Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. EXPERIMENTAL GERONTOLOGY. 90:1-13.Full Text via DOI: 10.1016/j.exger.2017.01.013 PMID: 28108329
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2017Relationship among physical activity, sedentary behaviors, and cardiometabolic risk factors during gastric bypass surgery-induced weight loss. SURGERY FOR OBESITY AND RELATED DISEASES. 13:210-219.Full Text via DOI: 10.1016/j.soard.2016.08.493 PMID: 27789136
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2016Age-related changes in skeletal muscle function: the sum of the parts could be greater than the whole Reply. JOURNAL OF APPLIED PHYSIOLOGY. 1235-1235.Full Text via DOI: 10.1152/japplphysiol.00832.2016 PMID: 27881626
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2016Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96years from the Baltimore Longitudinal Study of Aging. AGING CELL. 15:825-831.Full Text via DOI: 10.1111/acel.12491 PMID: 27135629
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2016Improved single muscle fiber quality in the oldest-old. JOURNAL OF APPLIED PHYSIOLOGY. 121:878-884.Full Text via DOI: 10.1152/japplphysiol.00479.2016 PMID: 27516537
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2016The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. EXPERIMENTAL GERONTOLOGY. 81:1-7.Full Text via DOI: 10.1016/j.exger.2016.04.002 PMID: 27084585
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2016Resting and exercise energy metabolism in weight-reduced adults with severe obesity. OBESITY. 24:1290-1298.Full Text via DOI: 10.1002/oby.21501 PMID: 27129892
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2016A role for exercise after bariatric surgery?. DIABETES OBESITY & METABOLISM. 16-23.Full Text via DOI: 10.1111/dom.12545 PMID: 26228356
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2015Dose Response of Exercise Training Following Roux-en-Y Gastric Bypass Surgery: A Randomized Trial. OBESITY. 23:2454-2461.Full Text via DOI: 10.1002/oby.21332 PMID: 26537198
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2015Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery. DIABETES. 64:3737-3750.Full Text via DOI: 10.2337/db15-0809 PMID: 26293505
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2015Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 70:1379-1385.Full Text via DOI: 10.1093/gerona/glu134 PMID: 25167867
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2015Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity. JOURNAL OF CLINICAL INVESTIGATION. 125:248-257.Full Text via DOI: 10.1172/JCI78016 PMID: 25437877
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2014Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 307:E1117-E1124.Full Text via DOI: 10.1152/ajpendo.00257.2014 PMID: 25352435
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2014Racial Differences In Peripheral Insulin Sensitivity and Mitochondrial Capacity in the Absence of Obesity. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:4307-4314.Full Text via DOI: 10.1210/jc.2014-2512 PMID: 25105736
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2014Improved Mitochondrial Function Is Linked With Improved Insulin Sensitivity Through Reductions in FFA. DIABETES. 2611-2612.Full Text via DOI: 10.2337/db14-0277 PMID: 25060892
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2014Skeletal muscle as a regulator of the longevity protein, Klotho. FRONTIERS IN PHYSIOLOGY. 5.Full Text via DOI: 10.3389/fphys.2014.00189 PMID: 24987372
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2014Exercise Training Modifies Ghrelin and Adiponectin Concentrations and Is Related to Inflammation in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 69:675-681.Full Text via DOI: 10.1093/gerona/glt132 PMID: 24013674
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2014Regular Exercise Improves Insulin Sensitivity and Muscle Mitochondrial Respiration Following Gastric Bypass Surgery. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 794-795.
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2014Skeletal Muscle Mitochondrial Respiration And Expression Of Quality Control Proteins Are Unaffected By Aging. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 298-298.
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2014Identification of Distinct Monocyte Phenotypes and Correlation With Circulating Cytokine Profiles in Acute Response to Spinal Cord Injury: A Pilot Study. PM&R. 6:332-341.Full Text via DOI: 10.1016/j.pmrj.2013.10.006 PMID: 24140737
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2014Dynamic PET Imaging Reveals Heterogeneity of Skeletal Muscle Insulin Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:E102-E106.Full Text via DOI: 10.1210/jc.2013-2095 PMID: 24170108
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2013Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglycerol Content in Severe Obesity. OBESITY. 21:2362-2371.Full Text via DOI: 10.1002/oby.20381 PMID: 23512750
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2013Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. DIABETES. 62:3350-3361.Full Text via DOI: 10.2337/db13-0500 PMID: 23835334
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2013HETEROGENEOUS EFFECT OF AGING ON MUSCLE EFFICIENCY. JOURNAL OF APPLIED PHYSIOLOGY. 1114-1114.PMID: 23588541
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2013Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 68:447-455.Full Text via DOI: 10.1093/gerona/gls196 PMID: 23051977
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2012Role of intramyocelluar lipids in human health. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 391-398.Full Text via DOI: 10.1016/j.tem.2012.05.009 PMID: 22721584
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2012Do Acute Exercise and Diet Reveal the Molecular Basis for Metabolic Flexibility in Skeletal Muscle?. DIABETES. 983-983.Full Text via DOI: 10.2337/db12-0152 PMID: 22517651
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2011Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance Another Paradox in Endurance-Trained Athletes?. DIABETES. 60:2588-2597.Full Text via DOI: 10.2337/db10-1221 PMID: 21873552
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2011Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. DIABETOLOGIA. 54:1147-1156.Full Text via DOI: 10.1007/s00125-011-2065-0 PMID: 21327867
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2011Skeletal Muscle Mitochondria in Insulin Resistance: Differences in Intermyofibrillar Versus Subsarcolemmal Subpopulations and Relationship to Metabolic Flexibility. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:494-503.Full Text via DOI: 10.1210/jc.2010-0822 PMID: 21106709
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2010Adding exercise to rosuvastatin treatment influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population. METABOLISM-CLINICAL AND EXPERIMENTAL. 59:1775-1783.Full Text via DOI: 10.1016/j.metabol.2010.05.002 PMID: 20580035
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2010Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 400:318-322.Full Text via DOI: 10.1016/j.bbrc.2010.08.053 PMID: 20727852
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2010Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content. DIABETES. 59:80-88.Full Text via DOI: 10.2337/db09-0988 PMID: 19833891
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2009Physical Inactivity and Obesity Underlie the Insulin Resistance of Aging. DIABETES CARE. 32:1547-1549.Full Text via DOI: 10.2337/dc09-0267 PMID: 19401446
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2009Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage. METABOLISM-CLINICAL AND EXPERIMENTAL. 58:1030-1038.Full Text via DOI: 10.1016/j.metabol.2009.03.006 PMID: 19411087
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2008Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?. JOURNAL OF LEUKOCYTE BIOLOGY. 84:1271-1278.Full Text via DOI: 10.1189/jlb.0408244 PMID: 18664531
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2007The influence of exercise training on inflammatory cytokines and C-reactive protein. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 39:1714-1719.Full Text via DOI: 10.1249/mss.0b013e31811ece1c PMID: 17909397
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2006Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 61:388-393.PMID: 16611706
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2005Influence of exercise training and age on CD14+cell-surface expression of toll-like receptor 2 and 4. BRAIN BEHAVIOR AND IMMUNITY. 19:389-397.PMID: 15963685
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2004Modulatiori of nitric oxide and 6-keto-prostaglandin F-1 alpha production in bovine aortic endothelial cells by conjugated linoleic acid. ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH. 11:211-220.Full Text via DOI: 10.1080/10623320490512435 PMID: 15370299
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2004Regulation of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: Role of Gi protein signaling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 24:457-463.Full Text via DOI: 10.1161/01.ATV.0000117176.71143.a1 PMID: 14726412
Research
principal investigator on
- BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence 2019 - 2024
- Grant: The role of exercise on skeletal muscle recovery following bed rest in older adults with T2D. Study: Exercise Training as an Intervention to Improve Muscle Function and Recovery Following Bed Rest in Older Adults With Type 2 Diabetes (RECOVER) 2018 - 2023
- The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults 2018 - 2023
- A Novel Role for Brown Adipose Tissue Enhance Heart Function and Metabolism 2017 - 2022
- Electrical Stimulation of Human Myocytes in Microgravity: An In Vitro Model to Evaluate Therapeutics to Counteract Muscle Wasting 2020 - 2021
Background
Full Name
- Paul M Coen, PhD
Education
- Purdue University, West Lafayette, IN
Fellowship
- University of Pittsburgh School of Medicine
Contact
primary email
- Research.Institute@AdventHealth.com