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Sparks, Lauren M, PhD
Overview
overview
- Dr. Lauren M. Sparks is an Investigator at the Translational Research Institute. Dr. Sparks pursues investigations on the topics of exercise response variation. Dr. Sparks is interested in understanding why some individuals do not respond favorably to exercise as a means of improving their metabolism and related co-morbidities. She aims to advance the field of exercise and type 2 diabetes and potentially shift the paradigm, allowing interventions to be targeted to those individuals most likely to benefit as well as identify novel approaches to treat those who do not. Dr. Sparks investigates the communication between muscle and fat tissue and how some individuals who are obese, but metabolically healthy, differ from those individuals who are obese and metabolically unhealthy. Prior to joining the TRI, Dr. Sparks was a postdoctoral scientist at Maastricht University in the Netherlands from 2009-2012. She focused on exercise and mitochondrial function in muscle and brown adipose tissue. From 2006-2009, Dr. Sparks was a postdoctoral fellow at Pennington Biomedical Research Center in Baton Rouge, Louisiana with a focus on exercise and substrate metabolism in type 2 diabetes. Dr. Lauren Sparks was born in Patterson, Louisiana. She earned a B.S. in Zoology and a B.A. in Spanish in 2002 and continued on to earn her PhD in Molecular Biology in 2006 from Louisiana State University.
Affiliation
Member of
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Clinical Program
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Research Department
Publications
Most Recent Publications
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2024Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis. ARTHRITIS & RHEUMATOLOGY.Full Text via DOI: 10.1002/art.42953 PMID: 39016102
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2024Aging human abdominal subcutaneous white adipose tissue at single cell resolution. AGING CELL.Full Text via DOI: 10.1111/acel.14287 PMID: 39141531
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2024Leveraging real-world data to predict cancer cachexia stage, quality of life, and survival in a racially and ethnically diverse multi-institutional cohort of treatment-naïve patients with pancreatic ductal adenocarcinoma. FRONTIERS IN ONCOLOGY. 14.Full Text via DOI: 10.3389/fonc.2024.1362244 PMID: 39109281
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2024Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae101 PMID: 38605684
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2024The mitochondrial multi-omic response to exercise training across rat tissues. CELL METABOLISM. 36.Full Text via DOI: 10.1016/j.cmet.2023.12.021 PMID: 38701776
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2024Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. OBESITY. 32:1125-1135.Full Text via DOI: 10.1002/oby.24008 PMID: 38803308
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2024Isolation of Nuclei from Human Intermuscular Adipose Tissue and Downstream Single-Nuclei RNA Sequencing. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/66784 PMID: 38767365
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2024Myokine Secretion following an Aerobic Exercise Intervention in Individuals with Type 2 Diabetes with or without Exercise Resistance. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25.Full Text via DOI: 10.3390/ijms25094889 PMID: 38732106
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2024Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. NATURE METABOLISM. 6.Full Text via DOI: 10.1038/s42255-023-00959-9 PMID: 38693320
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2024Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 326:C1248-C1261.Full Text via DOI: 10.1152/ajpcell.00726.2023 PMID: 38581663
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2024Understanding the variation in exercise responses to guide personalized physical activity prescriptions. CELL METABOLISM. 702-724.Full Text via DOI: 10.1016/j.cmet.2023.12.025 PMID: 38262420
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2024Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. ELIFE. 12.Full Text via DOI: 10.7554/eLife.88863 PMID: 38224289
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2024Translating In Vitro Models of Exercise in Human Muscle Cells: A Mitocentric View. EXERCISE AND SPORT SCIENCES REVIEWS. 3-12.Full Text via DOI: 10.1249/JES.0000000000000330 PMID: 38126401
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2023CARDIORESPIRATORY FITNESS IS ASSOCIATED WITH CIRCADIAN BEHAVIORAL PARAMETERS OF PHYSICAL ACTIVITY IN OLDER ADULTS. INNOVATION IN AGING. 379-379.
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2023Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 325:E291-E302.Full Text via DOI: 10.1152/ajpendo.00143.2023 PMID: 37584609
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2023Isolation of nuclei from frozen human subcutaneous adipose tissue for full-length single-nuclei transcriptional profiling. STAR PROTOCOLS. 4.Full Text via DOI: 10.1016/j.xpro.2023.102054 PMID: 36853719
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2023Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue. ISCIENCE. 26.Full Text via DOI: 10.1016/j.isci.2023.106189 PMID: 36895649
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2022Intermuscular adipose tissue in metabolic disease. NATURE REVIEWS ENDOCRINOLOGY.Full Text via DOI: 10.1038/s41574-022-00784-2 PMID: 36564490
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2022Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glac238 PMID: 36462195
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2022Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary. GEROSCIENCE.Full Text via DOI: 10.1007/s11357-022-00668-3 PMID: 36242693
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2022Aerobic training increases mitochondrial respiratory capacity in human skeletal muscle stem cells from sedentary individuals. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 323:C606-C616.Full Text via DOI: 10.1152/ajpcell.00146.2022 PMID: 35785986
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2022Increased liver fat associates with severe metabolic perturbations in low birth weight men. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 186:511-521.Full Text via DOI: 10.1530/EJE-21-1221 PMID: 35212643
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2022Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 322:E260-E277.Full Text via DOI: 10.1152/ajpendo.00378.2021 PMID: 35068187
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2021The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?. DIABETES. 2457-2467.Full Text via DOI: 10.2337/dbi19-0006 PMID: 34711670
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2021A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity. JOURNAL OF THE ENDOCRINE SOCIETY. 5.Full Text via DOI: 10.1210/jendso/bvab118 PMID: 34337278
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2021Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training. DIABETOLOGIA.Full Text via DOI: 10.1007/s00125-021-05535-y PMID: 34402932
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2021Prolonged Glucagon Infusion Does Not Affect Energy Expenditure in Individuals with Overweight/Obesity: A Randomized Trial. OBESITY. 29:1003-1013.Full Text via DOI: 10.1002/oby.23141 PMID: 34029448
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2021A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. CIRCULATION. 143:145-159.Full Text via DOI: 10.1161/CIRCULATIONAHA.120.049813 PMID: 33106031
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2020Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults. FRONTIERS IN ENDOCRINOLOGY. 11.Full Text via DOI: 10.3389/fendo.2020.00632 PMID: 33013705
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2020An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. PHYSIOLOGICAL REPORTS. 8.Full Text via DOI: 10.14814/phy2.14416 PMID: 32562350
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2020Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women. FRONTIERS IN PHYSIOLOGY. 11.Full Text via DOI: 10.3389/fphys.2020.00018 PMID: 32132925
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2019Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality. NUTRIENTS.Full Text via DOI: 10.3390/nu11112553 PMID: 31652734
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2019Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes. PHYSIOLOGICAL GENOMICS. 51:586-595.Full Text via DOI: 10.1152/physiolgenomics.00014.2019 PMID: 31588872
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2019Precision exercise medicine: understanding exercise response variability. BRITISH JOURNAL OF SPORTS MEDICINE. 53:1141-1153.Full Text via DOI: 10.1136/bjsports-2018-100328 PMID: 30862704
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2019Targeting White Adipose Tissue with Exercise or Bariatric Surgery as Therapeutic Strategies in Obesity. BIOLOGY-BASEL.Full Text via DOI: 10.3390/biology8010016 PMID: 30875990
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2019GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. CELL METABOLISM. 29:707-+.Full Text via DOI: 10.1016/j.cmet.2018.12.016 PMID: 30639358
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2018Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes. DIABETES CARE. 41:2245-2254.Full Text via DOI: 10.2337/dc18-0296 PMID: 30072402
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2018HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI INSIGHT. 3.Full Text via DOI: 10.1172/jci.insight.120159 PMID: 30089714
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2018Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training. FRONTIERS IN PHYSIOLOGY. 9.Full Text via DOI: 10.3389/fphys.2018.00704 PMID: 29942262
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2018Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 314:E165-E173.Full Text via DOI: 10.1152/ajpendo.00266.2017 PMID: 29118014
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2018Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans. OBESITY. 26:135-140.Full Text via DOI: 10.1002/oby.22062 PMID: 29178600
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2018Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. MOLECULAR METABOLISM. 7:1-11.Full Text via DOI: 10.1016/j.molmet.2017.10.012 PMID: 29146412
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2017Exercise training response heterogeneity: physiological and molecular insights. DIABETOLOGIA. 2329-2336.Full Text via DOI: 10.1007/s00125-017-4461-6 PMID: 29032385
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2017Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue. INTERNATIONAL JOURNAL OF OBESITY. 41:1646-1653.Full Text via DOI: 10.1038/ijo.2017.155 PMID: 28674442
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2017Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome. MOLECULAR METABOLISM. 6:703-714.Full Text via DOI: 10.1016/j.molmet.2017.05.001 PMID: 28702326
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2017Metabolic Flexibility in Health and Disease. CELL METABOLISM. 1027-1036.Full Text via DOI: 10.1016/j.cmet.2017.04.015 PMID: 28467922
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2017Pioglitazone-induced improvements in insulin sensitivity occur without concomitant changes in muscle mitochondrial function. METABOLISM-CLINICAL AND EXPERIMENTAL. 69:24-32.Full Text via DOI: 10.1016/j.metabol.2016.11.016 PMID: 28285649
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2017Resistance training to improve type 2 diabetes: working toward a prescription for the future. NUTRITION & METABOLISM.Full Text via DOI: 10.1186/s12986-017-0173-7 PMID: 28270856
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2017Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 102:111-121.Full Text via DOI: 10.1210/jc.2016-3211 PMID: 27778643
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2016Active Individuals have High Mitochondrial Content and Oxidative Markers in Their Abdominal Subcutaneous Adipose Tissue. OBESITY. 24:2467-2470.Full Text via DOI: 10.1002/oby.21669 PMID: 27804230
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2016Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 101:4994-5003.Full Text via DOI: 10.1210/jc.2016-2742 PMID: 27710240
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2016ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. DIABETOLOGIA. 59:1030-1039.Full Text via DOI: 10.1007/s00125-016-3885-8 PMID: 26886198
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2015Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. INTERNATIONAL JOURNAL OF OBESITY. 39:1607-1618.Full Text via DOI: 10.1038/ijo.2015.104 PMID: 26041698
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2015A transcriptional signature of "exercise resistance" in skeletal muscle of individuals with type 2 diabetes mellitus. METABOLISM-CLINICAL AND EXPERIMENTAL. 64:999-1004.Full Text via DOI: 10.1016/j.metabol.2015.06.008 PMID: 26163877
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2015Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans. DIABETES. 64:1193-1201.Full Text via DOI: 10.2337/db14-0667 PMID: 25352640
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2015Resistance to the Beneficial Effects of Exercise in Type 2 Diabetes: Are Some Individuals Programmed to Fail?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 100:43-52.Full Text via DOI: 10.1210/jc.2014-2545 PMID: 25412336
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2014Reduced Incorporation of Fatty Acids Into Triacylglycerol in Myotubes From Obese Individuals With Type 2 Diabetes. DIABETES. 63:1583-1593.Full Text via DOI: 10.2337/db13-1123 PMID: 24487026
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2014PGC1 alpha-1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals. PPAR RESEARCH.Full Text via DOI: 10.1155/2014/895734 PMID: 25614734
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2013Increased Oxygen Consumption in Human Adipose Tissue From the "Brown Adipose Tissue" Region. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 98:E1230-E1234.Full Text via DOI: 10.1210/jc.2013-1348 PMID: 23783102
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2013Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0062973 PMID: 23805175
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2013Nine Months of Combined Training Improves Ex Vivo Skeletal Muscle Metabolism in Individuals With Type 2 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 98:1694-1702.Full Text via DOI: 10.1210/jc.2012-3874 PMID: 23463651
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2013Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1831:844-852.Full Text via DOI: 10.1016/j.bbalip.2013.01.007 PMID: 23353597
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2013Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy. CIRCULATION RESEARCH. E51-E54.Full Text via DOI: 10.1161/CIRCRESAHA.113.300944 PMID: 23449549
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2013Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0051648 PMID: 23418416
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2013PPAR gamma coactivator-1 alpha contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. JOURNAL OF LIPID RESEARCH. 54:522-534.Full Text via DOI: 10.1194/jlr.P028910 PMID: 23175776
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2012Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome. METABOLISM-CLINICAL AND EXPERIMENTAL. 61:1554-1565.Full Text via DOI: 10.1016/j.metabol.2012.04.003 PMID: 22658938
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2012Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels. DIABETES. 61:2679-2690.Full Text via DOI: 10.2337/db11-1402 PMID: 22807032
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2012High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance. DIABETES. 61:2472-2478.Full Text via DOI: 10.2337/db11-1832 PMID: 22787138
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2012Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human. CELL. 150:366-376.Full Text via DOI: 10.1016/j.cell.2012.05.016 PMID: 22796012
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2012Low Macrophage Accumulation in Skeletal Muscle of Obese Type 2 Diabetics and Elderly Subjects. OBESITY. 20:1530-1533.Full Text via DOI: 10.1038/oby.2012.24 PMID: 22314623
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2012The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. HISTOCHEMISTRY AND CELL BIOLOGY. 137:205-216.Full Text via DOI: 10.1007/s00418-011-0888-x PMID: 22127648
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2011Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance. OBESITY. 19:2158-2166.Full Text via DOI: 10.1038/oby.2011.149 PMID: 21701566
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2011Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes. PLOS ONE. 6.Full Text via DOI: 10.1371/journal.pone.0021068 PMID: 21760887
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2011Palmitate-induced skeletal muscle insulin resistance does not require NF-kappa B activation. CELLULAR AND MOLECULAR LIFE SCIENCES. 68:1215-1225.Full Text via DOI: 10.1007/s00018-010-0515-3 PMID: 20820848
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2010Effects of Aerobic and Resistance Training on Hemoglobin A(1c) Levels in Patients With Type 2 Diabetes A Randomized Controlled Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 304:2253-2262.PMID: 21098771
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2009Effect of adipose tissue on the sexual dimorphism in metabolic flexibility. METABOLISM-CLINICAL AND EXPERIMENTAL. 58:1564-1571.Full Text via DOI: 10.1016/j.metabol.2009.05.008 PMID: 19595383
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2009Subtyping obesity with microarrays: implications for the diagnosis and treatment of obesity. INTERNATIONAL JOURNAL OF OBESITY. 33:481-489.Full Text via DOI: 10.1038/ijo.2008.277 PMID: 19188926
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2009Relation of adipose tissue to metabolic flexibility. DIABETES RESEARCH AND CLINICAL PRACTICE. 83:32-43.Full Text via DOI: 10.1016/j.diabres.2008.09.052 PMID: 19038471
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2008Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 93:233-239.Full Text via DOI: 10.1210/jc.2007-1535 PMID: 17925338
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2007Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. DIABETOLOGIA. 50:2526-2533.Full Text via DOI: 10.1007/s00125-007-0818-6 PMID: 17879081
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2006High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loop. METABOLISM-CLINICAL AND EXPERIMENTAL. 55:1457-1463.Full Text via DOI: 10.1016/j.metabol.2006.07.003 PMID: 17046547
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2005A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. DIABETES. 54:1926-1933.PMID: 15983191
Research
principal investigator on
- Investigating the effects of aerobic and resistance training in vivo on skeletal muscle metabolism in vitro in primary human muscle cells 2019 - 2024
- Mechanisms of Prediabetic States in Obstructive Sleep Apnea 2019 - 2021
- Investigating the direct effects of fibro-adipogenic progenitor cells on skeletal muscle regenerative capacity and insulin resistance in patients with Duchenne muscular dystrophy 2019 - 2021
- Investigating the role of adipose tissue in mobility and aging 2020 - 2021
Background
Full Name
- Lauren M Sparks, PhD
Education
- Louisiana State University, Baton Rouge, LA
Contact
primary email
- Research.Institute@AdventHealth.com