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Goodpaster, Bret H, PhD
Overview
overview
- Bret Goodpaster, Ph.D. investigates the pathophysiology of human aging, obesity, insulin resistance, and diabetes, and the biological mechanisms underlying the health benefits of exercise. Dr. Goodpaster has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Which are the good fats and which are the bad fats? Dr. Goodpaster has published >250 peer-reviewed papers, review articles and book chapters, has served on several Editorial Boards, and is currently an Associate Editor for Diabetologia. He has served on grant review panels for the NIH and the American Diabetes Association. Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University. Prior to coming to the AdventHealth Translational Research Institute, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.
research areas
- Cardiovascular System & Cardiology
- Cell Biology
- Endocrinology & Metabolism
- Gastroenterology & Hepatology
- General & Internal Medicine
- Genetics & Heredity
- Geriatrics & Gerontology
- Neurosciences & Neurology
- Nutrition & Dietetics
- Physiology
- Psychiatry
- Research & Experimental Medicine
- Sport Sciences
- Surgery
Affiliation
Member of
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Clinical Program
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Research Department
Publications
Most Recent Publications
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2024Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. FREE RADICAL BIOLOGY AND MEDICINE. 223:384-397.Full Text via DOI: 10.1016/j.freeradbiomed.2024.07.039 PMID: 39097206
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2024Cardiopulmonary Exercise Testing in a Prospective Multicenter Cohort of Older Adults. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 56:1574-1584.Full Text via DOI: 10.1249/MSS.0000000000003444 PMID: 38598351
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2024Cardiopulmonary Exercise Testing in a Prospective Multicenter Cohort of Older Adults. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 56:1574-1584.Full Text via DOI: 10.1249/MSS.0000000000003444
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2024Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA). JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae187 PMID: 39066507
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2024Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis. ARTHRITIS & RHEUMATOLOGY.Full Text via DOI: 10.1002/art.42953 PMID: 39016102
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2024Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). JOURNAL OF SPORT AND HEALTH SCIENCE. 13:621-630.Full Text via DOI: 10.1016/j.jshs.2024.02.001 PMID: 38341136
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2024Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae101 PMID: 38605684
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2024The mitochondrial multi-omic response to exercise training across rat tissues. CELL METABOLISM. 36.Full Text via DOI: 10.1016/j.cmet.2023.12.021 PMID: 38701776
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2024Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. OBESITY. 32:1125-1135.Full Text via DOI: 10.1002/oby.24008 PMID: 38803308
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2024Isolation of Nuclei from Human Intermuscular Adipose Tissue and Downstream Single-Nuclei RNA Sequencing. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/66784 PMID: 38767365
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2024Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. NATURE METABOLISM. 6.Full Text via DOI: 10.1038/s42255-023-00959-9 PMID: 38693320
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2024Understanding the variation in exercise responses to guide personalized physical activity prescriptions. CELL METABOLISM. 702-724.Full Text via DOI: 10.1016/j.cmet.2023.12.025 PMID: 38262420
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2024Associations Between D3Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae056 PMID: 38367212
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2024Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae047 PMID: 38366047
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2024Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glad283 PMID: 38150179
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2024The Association of Skeletal Muscle Energetics With Recurrent Falls in Older Adults Within the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae018 PMID: 38206375
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2024Chronic exercise improves hepatic acylcarnitine handling. ISCIENCE. 27.Full Text via DOI: 10.1016/j.isci.2024.109083 PMID: 38361627
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2023Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY.Full Text via DOI: 10.1111/jgs.18713 PMID: 38149438
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2023ASSOCIATION OF DIABETES WITH BODY COMPOSITION, CARDIORESPIRATORY FITNESS, AND MITOCHONDRIAL ENERGETICS. INNOVATION IN AGING. 640-640.
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2023CARDIORESPIRATORY FITNESS AND MITOCHONDRIAL ENERGETICS IN THE OLDEST OLD: THE STUDY OF MUSCLE, MOBILITY AND AGING. INNOVATION IN AGING. 639-639.
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2023ESTIMATING CARDIORESPIRATORY FITNESS USING A USUAL-PACED 400 M-LONG DISTANCE CORRIDOR WALK IN OLDER ADULTS. INNOVATION IN AGING. 378-379.
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2023GENDER DIFFERENCES IN SKELETAL MUSCLE ENERGETICS EXPLAIN THE MOBILITY IMPAIRMENT DISPARITY IN SOMMA. INNOVATION IN AGING. 639-639.
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2023MITOCHONDRIAL ENERGETICS AND PERCEIVED PHYSICAL FATIGABILITY SEVERITY IN OLDER ADULTS. INNOVATION IN AGING. 378-378.
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2023Vigor to Frailty As a Continuum-A New Approach in the Study of Muscle, Mobility, and Aging Cohort. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glad244 PMID: 37847228
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2023Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging. AGING CELL.Full Text via DOI: 10.1111/acel.14015 PMID: 37843879
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2023Mitochondrial Energeticsand Performance Fatigability In Older Adults: Study Of Muscle, Mobility, And Aging (SOMMA). MEDICINE & SCIENCE IN SPORTS & EXERCISE. 166-166.
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2023Reduced Muscle Energetics And Fitness In Older Adults With Diabetes Independent Of Adiposity And Activity. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 166-166.
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2023Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glad197 PMID: 37566383
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2023Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY.Full Text via DOI: 10.1111/jgs.18419 PMID: 37282843
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2023Associations Between Circulating Levels of Myostatin and Plasma beta-Amyloid 42/40 in a Biracial Cohort of Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glad132 PMID: 37220890
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2023Lower mitochondrial respiration does not lead to decreased fat oxidation in young African American women without obesity. OBESITY. 31:1338-1346.Full Text via DOI: 10.1002/oby.23716 PMID: 37140394
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2023Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults. JOURNAL OF PHYSIOLOGY-LONDON.Full Text via DOI: 10.1113/JP284142 PMID: 36814134
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2023The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glad052 PMID: 36754371
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2023Dual Roles of Cardiorespiratory Fitness and Fatigability in the Life-Space Mobility of Older Adults: The Study of Muscle, Mobility and Aging (SOMMA). JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glad037 PMID: 36715332
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2022Intermuscular adipose tissue in metabolic disease. NATURE REVIEWS ENDOCRINOLOGY.Full Text via DOI: 10.1038/s41574-022-00784-2 PMID: 36564490
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2022Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glac238 PMID: 36462195
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2022DUAL ROLES OF FITNESS AND FATIGABILITY IN THE LIFE- SPACE MOBILITY OF OLDER ADULTS. INNOVATION IN AGING. 369-369.
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2022INTERMUSCULAR ADIPOSITY: A NOVEL RISK FACTOR FOR COGNITIVE DECLINE IN A BIRACIAL COHORT OF OLDER ADULTS. INNOVATION IN AGING. 332-332.
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2022INTRODUCTION TO SOMMA: CONCEPTUAL CONSTRUCT AND PARTICIPANT CHARACTERISTICS. INNOVATION IN AGING. 208-208.
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2022PRELIMINARY SOMMA DATA: COGNITIVE AND PHYSICAL FUNCTION RELATIONSHIPS IN OLDER ADULTS. INNOVATION IN AGING. 209-209.
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2022PRELIMINARY SOMMA DATA: D3CR MUSCLE MASS AND STRENGTH AND WALKING SPEED IN OLDER MEN AND WOMEN. INNOVATION IN AGING. 209-209.
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2022PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS. INNOVATION IN AGING. 209-209.
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2022RECRUITMENT OF SOMMA PARTICIPANTS: TECHNIQUES TO ENROLL OLDER ADULTS IN A COMPLEX STUDY. INNOVATION IN AGING. 208-209.
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2022SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS. INNOVATION IN AGING. 808-808.
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2022VALIDATION OF THE PITTSBURGH PERFORMANCE FATIGABILITY INDEX FROM USUAL-PACED 400 M WALK. INNOVATION IN AGING. 368-368.
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2022Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary. GEROSCIENCE.Full Text via DOI: 10.1007/s11357-022-00668-3 PMID: 36242693
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2022Reply to 'Lactate as a major myokine and exerkine'. NATURE REVIEWS ENDOCRINOLOGY. 713-713.Full Text via DOI: 10.1038/s41574-022-00726-y PMID: 35915255
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2022Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. DRUGS-REAL WORLD OUTCOMES. 9:359-375.Full Text via DOI: 10.1007/s40801-022-00303-9 PMID: 35809196
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2022Muscle Quality in Skeletal Muscle Function Deficit: Recent Advances and Potential Clinical and Therapeutic Implications. FRONTIERS IN PHYSIOLOGY.Full Text via DOI: 10.3389/fphys.2022.847883 PMID: 35530506
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2022Exerkines in health, resilience and disease. NATURE REVIEWS ENDOCRINOLOGY. 273-289.Full Text via DOI: 10.1038/s41574-022-00641-2 PMID: 35304603
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2022Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 322:E260-E277.Full Text via DOI: 10.1152/ajpendo.00378.2021 PMID: 35068187
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2022State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.. Comprehensive Physiology. 3193-3279.Full Text via DOI: 10.1002/cphy.c200033 PMID: 35578962
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2021The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?. DIABETES. 2457-2467.Full Text via DOI: 10.2337/dbi19-0006 PMID: 34711670
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2021Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glab240 PMID: 34406407
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2021Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training. DIABETOLOGIA.Full Text via DOI: 10.1007/s00125-021-05535-y PMID: 34402932
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2021Estimating cardiorespiratory fitness in older adults using a usual-paced 400-m long-distance corridor walk. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY.Full Text via DOI: 10.1111/jgs.17360 PMID: 34269423
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2021Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity A Phase 2 Randomized Clinical Trial. JAMA NETWORK OPEN. 4.Full Text via DOI: 10.1001/jamanetworkopen.2020.33457 PMID: 33439265
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2021A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. CIRCULATION. 143:145-159.Full Text via DOI: 10.1161/CIRCULATIONAHA.120.049813 PMID: 33106031
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2021ASSESSING MITOCHONDRIAL ENERGETICS OF SKELETAL MUSCLE IN THE STUDY OF MUSCLE MOBILITY AND AGING (SOMMA). INNOVATION IN AGING. 125-125.
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2021ASSOCIATIONS OF BODY COMPOSITION AND MITOCHONDRIAL FUNCTION IN OLDER ADULTS. INNOVATION IN AGING. 125-126.
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2021INITIAL RESULTS FROM SOMMA: CONTRIBUTION OF MITOCHONDRIAL FUNCTION TO WALKING AND FITNESS. INNOVATION IN AGING. 124-125.
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2021MUSCLE QUALITY REVISITED: BIOPSY ENERGETICS, MR SPECTROSCOPY, AND MUSCLE POWER AND STRENGTH. INNOVATION IN AGING. 125-125.
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2021The Relationship Between Intermuscular Fat and Physical Performance Is Moderated by Muscle Area in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 76:115-122.Full Text via DOI: 10.1093/gerona/glaa161 PMID: 32614950
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2020Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction JACC State-of-the-Art Review. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 1166-1187.Full Text via DOI: 10.1016/j.jacc.2021.07.014 PMID: 34503685
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2020Muscle insulin resistance in type 1 diabetes with coronary artery disease. DIABETOLOGIA. 63:2665-2674.Full Text via DOI: 10.1007/s00125-020-05270-w PMID: 32926189
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2020Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults. FRONTIERS IN ENDOCRINOLOGY. 11.Full Text via DOI: 10.3389/fendo.2020.00632 PMID: 33013705
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2020Effects of Oral Sodium Nitrite on Blood Pressure, Insulin Sensitivity, and Intima-Media Arterial Thickening in Adults With Hypertension and Metabolic Syndrome. HYPERTENSION. 76:866-874.Full Text via DOI: 10.1161/HYPERTENSIONAHA.120.14930 PMID: 32755471
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2020Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 75:1744-1753.Full Text via DOI: 10.1093/gerona/glaa001 PMID: 31907525
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2020Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging. FRONTIERS IN PHYSIOLOGY.Full Text via DOI: 10.3389/fphys.2020.00963 PMID: 32903666
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2020CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance. JOURNAL OF PHYSIOLOGY-LONDON. 3803-3806.Full Text via DOI: 10.1113/JP278219 PMID: 32643165
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2020Rebuttal from Bret H. Goodpaster. JOURNAL OF PHYSIOLOGY-LONDON. 3811-3811.Full Text via DOI: 10.1113/JP279714 PMID: 32643157
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2020Validity And Reliability Of Small Respiratory Chamber To Assess Exercise Energy Expenditure. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 43-43.
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2020Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. SCIENTIFIC REPORTS. 10.Full Text via DOI: 10.1038/s41598-020-67300-2 PMID: 32591558
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2020Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise. FRONTIERS IN PHYSIOLOGY. 11.Full Text via DOI: 10.3389/fphys.2020.00605 PMID: 32587527
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2020Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles. AGING CELL. 19.Full Text via DOI: 10.1111/acel.13135 PMID: 32468656
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2020Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity. DIABETES. 69:848-858.Full Text via DOI: 10.2337/dbi18-0042 PMID: 32312901
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2020Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 105.Full Text via DOI: 10.1210/clinem/dgz272 PMID: 31833547
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2020Skeletal muscle fat in individuals with rheumatoid arthritis compared to healthy adults. EXPERIMENTAL GERONTOLOGY. 129.Full Text via DOI: 10.1016/j.exger.2019.110768 PMID: 31678218
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2019Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes. PHYSIOLOGICAL GENOMICS. 51:586-595.Full Text via DOI: 10.1152/physiolgenomics.00014.2019 PMID: 31588872
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2019Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 317:E899-E910.Full Text via DOI: 10.1152/ajpendo.00161.2019 PMID: 31479303
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2019Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome. SURGERY. 166:861-866.Full Text via DOI: 10.1016/j.surg.2019.04.017 PMID: 31253418
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2019Resting Energy Expenditure and Organ-Tissue Body Composition 5 Years After Bariatric Surgery. OBESITY SURGERY. 30:587-594.Full Text via DOI: 10.1007/s11695-019-04217-4 PMID: 31617114
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2019Precision exercise medicine: understanding exercise response variability. BRITISH JOURNAL OF SPORTS MEDICINE. 53:1141-1153.Full Text via DOI: 10.1136/bjsports-2018-100328 PMID: 30862704
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2019Trunk Muscle Composition 2 Months After Hip Fracture: Findings From the Baltimore Hip Studies. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 100:1663-1671.Full Text via DOI: 10.1016/j.apmr.2018.10.023 PMID: 30578772
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2019Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI INSIGHT. 4.Full Text via DOI: 10.1172/jci.insight.128248 PMID: 31120438
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2019LONG TERM RAT E S OF CHANGE I N MUSCULOSKELETAL AGING: FINDINGS FROM THE HEALTH, AGING AND BODY COMPOSITION STUDY. OSTEOPOROSIS INTERNATIONAL. S184-S184.
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2019Changes On Non-exercise Physical Activity Are Related To Improvements In Mitochondrial Function Independently Of Structured Intentional Exercise. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 773-773.
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2019Neuromuscular Electrical Stimulation Compared to Volitional Exercise for Improving Muscle Function in Rheumatoid Arthritis: A Randomized Pilot Study. ARTHRITIS CARE & RESEARCH. 71:352-361.Full Text via DOI: 10.1002/acr.23602 PMID: 29781580
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2018Comment on: "Pitfalls in the measurement of muscle mass: a need for a reference standard" by Buckinx et al.. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 1269-1271.Full Text via DOI: 10.1002/jcsm.12372 PMID: 30680964
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2018Implications of low muscle mass across the continuum of care: a narrative review. ANNALS OF MEDICINE. 675-693.Full Text via DOI: 10.1080/07853890.2018.1511918 PMID: 30169116
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2018Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes. DIABETES CARE. 41:2245-2254.Full Text via DOI: 10.2337/dc18-0296 PMID: 30072402
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2018Exercise and Bariatric Surgery: An Effective Therapeutic Strategy. EXERCISE AND SPORT SCIENCES REVIEWS. 262-270.Full Text via DOI: 10.1249/JES.0000000000000168 PMID: 30052546
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2018Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 73:1313-1322.Full Text via DOI: 10.1093/gerona/gly051 PMID: 29562317
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2018Weighty Matters in HFpEF and Aging. JACC-HEART FAILURE. 650-652.Full Text via DOI: 10.1016/j.jchf.2018.06.016 PMID: 30071951
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2018Fat-Free Mass and Skeletal Muscle Mass Five Years After Bariatric Surgery. OBESITY. 26:1130-1136.Full Text via DOI: 10.1002/oby.22190 PMID: 29845744
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2018Mitochondrial Respiration is Associated with Lower Energy Expenditure and Lower Aerobic Capacity in African American Women. OBESITY. 26:903-909.Full Text via DOI: 10.1002/oby.22163 PMID: 29687648
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2018Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. DIABETOLOGIA. 61:1142-1154.Full Text via DOI: 10.1007/s00125-018-4553-y PMID: 29428999
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2018Effects of Exercise and Aging on Skeletal Muscle. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 8.Full Text via DOI: 10.1101/cshperspect.a029785 PMID: 28432116
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2018Skeletal Muscle Fat and Its Association With Physical Function in Rheumatoid Arthritis. ARTHRITIS CARE & RESEARCH. 70:333-342.Full Text via DOI: 10.1002/acr.23278 PMID: 28482146
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2018Calorie Restriction-induced Weight Loss and Exercise Have Differential Effects on Skeletal Muscle Mitochondria Despite Similar Effects on Insulin Sensitivity. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 73:81-87.Full Text via DOI: 10.1093/gerona/glw328 PMID: 28158621
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2017Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding. OBESITY. 25:2079-2087.Full Text via DOI: 10.1002/oby.21980 PMID: 29071793
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2017Muscle fatigability and depressive symptoms in later life. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 32:E166-E172.Full Text via DOI: 10.1002/gps.4678 PMID: 28198046
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2017Effects of beta-hydroxy-beta-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. JOURNAL OF APPLIED PHYSIOLOGY. 123:1092-1100.Full Text via DOI: 10.1152/japplphysiol.00192.2017 PMID: 28705993
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2017Triheptanoin versus trioctanoin for long-chain fatty acid oxidation disorders: a double blinded, randomized controlled trial. JOURNAL OF INHERITED METABOLIC DISEASE. 40:831-843.Full Text via DOI: 10.1007/s10545-017-0085-8 PMID: 28871440
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2017Intramyocellular lipid droplets and insulin sensitivity, the human perspective. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1862:1242-1249.Full Text via DOI: 10.1016/j.bbalip.2017.07.010 PMID: 28739280
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2017Metabolites Associated With Lean Mass and Adiposity in Older Black Men. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 72:1352-1359.Full Text via DOI: 10.1093/gerona/glw245 PMID: 28052980
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2017Persistent Differences in MicroRNAs Responsive to Bariatric Surgery. AMERICAN JOURNAL OF GASTROENTEROLOGY. S588-S588.
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2017Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. HYPERTENSION. 70:634-+.Full Text via DOI: 10.1161/HYPERTENSIONAHA.117.09016 PMID: 28739973
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2017Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure. JOURNAL OF PHYSIOLOGY-LONDON. 595:5587-5601.Full Text via DOI: 10.1113/JP274374 PMID: 28560826
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2017Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 65:1427-1433.Full Text via DOI: 10.1111/jgs.14804 PMID: 28221668
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2017Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type-specific IMCL accumulation. JOURNAL OF APPLIED PHYSIOLOGY. 123:71-78.Full Text via DOI: 10.1152/japplphysiol.00209.2017 PMID: 28450549
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2017Gastric bypass surgery with exercise alters plasma microRNAs that predict improvements in cardiometabolic risk. INTERNATIONAL JOURNAL OF OBESITY. 41:1121-1130.Full Text via DOI: 10.1038/ijo.2017.84 PMID: 28344345
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2017Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB. OBESITY. 25:1206-1216.Full Text via DOI: 10.1002/oby.21864 PMID: 28558160
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2017Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 72:535-542.Full Text via DOI: 10.1093/gerona/glw102 PMID: 27325231
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2017Relationship among physical activity, sedentary behaviors, and cardiometabolic risk factors during gastric bypass surgery-induced weight loss. SURGERY FOR OBESITY AND RELATED DISEASES. 13:210-219.Full Text via DOI: 10.1016/j.soard.2016.08.493 PMID: 27789136
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2016Rebuttal from Scott A. Summers and Bret H. Goodpaster. JOURNAL OF PHYSIOLOGY-LONDON. 3175-3176.Full Text via DOI: 10.1113/JP272136 PMID: 26997478
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2015Asymmetry in CT Scan Measures of Thigh Muscle 2 Months After Hip Fracture: The Baltimore Hip Studies. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 70:1276-1280.Full Text via DOI: 10.1093/gerona/glv053 PMID: 25969469
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2015Sensory and Motor Peripheral Nerve Function and Longitudinal Changes in Quadriceps Strength. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 70:464-470.Full Text via DOI: 10.1093/gerona/glu183 PMID: 25320056
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2015A review of the relationship between leg power and selected chronic disease in older adults. JOURNAL OF NUTRITION HEALTH & AGING. 19:240-248.Full Text via DOI: 10.1007/s12603-014-0528-y PMID: 25651453
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2015Prevalence of Metabolic Syndrome and Its Association with Physical Capacity, Disability, and Self-Rated Health in Lifestyle Interventions and Independence for Elders Study Participants. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 63:222-232.Full Text via DOI: 10.1111/jgs.13205 PMID: 25645664
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2015Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity. JOURNAL OF CLINICAL INVESTIGATION. 125:248-257.Full Text via DOI: 10.1172/JCI78016 PMID: 25437877
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2015NIH Working Group Report: Innovative Research to Improve Maintenance of Weight Loss. OBESITY. 23:7-15.Full Text via DOI: 10.1002/oby.20967 PMID: 25469998
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2014Racial Differences In Peripheral Insulin Sensitivity and Mitochondrial Capacity in the Absence of Obesity. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:4307-4314.Full Text via DOI: 10.1210/jc.2014-2512 PMID: 25105736
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2014African American women exhibit similar adherence to intervention but lose less weight due to lower energy requirements. INTERNATIONAL JOURNAL OF OBESITY. 38:1147-1152.Full Text via DOI: 10.1038/ijo.2013.240 PMID: 24352292
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2014Surgical vs Medical Treatments for Type 2 Diabetes Mellitus A Randomized Clinical Trial. JAMA SURGERY. 149:707-715.Full Text via DOI: 10.1001/jamasurg.2014.467 PMID: 24899268
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2014Skeletal muscle as a regulator of the longevity protein, Klotho. FRONTIERS IN PHYSIOLOGY. 5.Full Text via DOI: 10.3389/fphys.2014.00189 PMID: 24987372
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2014Transition to Sarcopenia and Determinants of Transitions in Older Adults: A Population-Based Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 69:751-758.Full Text via DOI: 10.1093/gerona/glt131 PMID: 24013673
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2014Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults. AMERICAN JOURNAL OF CLINICAL NUTRITION. 99:1059-1065.Full Text via DOI: 10.3945/ajcn.113.080796 PMID: 24522448
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2014Regular Exercise Improves Insulin Sensitivity and Muscle Mitochondrial Respiration Following Gastric Bypass Surgery. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 794-795.
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2014Skeletal Muscle Mitochondrial Respiration And Expression Of Quality Control Proteins Are Unaffected By Aging. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 298-298.
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2014Body Composition Analysis by Air Displacement Plethysmography in Normal Weight to Extremely Obese Adults. OBESITY. 22:1078-1084.Full Text via DOI: 10.1002/oby.20655 PMID: 24170704
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2014Peripheral Nerve Function and Lower Extremity Muscle Power in Older Men. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 95:726-733.Full Text via DOI: 10.1016/j.apmr.2013.11.018 PMID: 24355427
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2014Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. PHYSIOLOGICAL GENOMICS. 46:149-158.Full Text via DOI: 10.1152/physiolgenomics.00169.2013 PMID: 24423970
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2014Effect of Physical Activity on Weight Loss, Energy Expenditure, and Energy Intake During Diet Induced Weight Loss. OBESITY. 22:363-370.Full Text via DOI: 10.1002/oby.20525 PMID: 23804562
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2014Adipose Tissue Density, a Novel Biomarker Predicting Mortality Risk in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 69:109-117.Full Text via DOI: 10.1093/gerona/glt070 PMID: 23707956
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2014Body Composition Explains Sex Differential in Physical Performance Among Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 69:93-100.Full Text via DOI: 10.1093/gerona/glt027 PMID: 23682159
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2014Dynamic PET Imaging Reveals Heterogeneity of Skeletal Muscle Insulin Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:E102-E106.Full Text via DOI: 10.1210/jc.2013-2095 PMID: 24170108
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2014THE IMPACT OF SARCOPENIA ON A PHYSICAL ACTIVITY INTERVENTION: THE LIFESTYLE INTERVENTIONS AND INDEPENDENCE FOR ELDERS PILOT STUDY (LIFE-P). JOURNAL OF NUTRITION HEALTH & AGING. 18:59-64.PMID: 24402391
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2013Elevated HbA(1c) and Fasting Plasma Glucose in Predicting Diabetes Incidence Among Older Adults Are two better than one?. DIABETES CARE. 36:3923-3929.Full Text via DOI: 10.2337/dc12-2631 PMID: 24135387
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2013Perivascular adipose tissue of the descending thoracic aorta is associated with systemic lupus erythematosus and vascular calcification in women. ATHEROSCLEROSIS. 231:129-135.Full Text via DOI: 10.1016/j.atherosclerosis.2013.09.004 PMID: 24125423
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2013Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglycerol Content in Severe Obesity. OBESITY. 21:2362-2371.Full Text via DOI: 10.1002/oby.20381 PMID: 23512750
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2013The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 379:30-34.Full Text via DOI: 10.1016/j.mce.2013.06.018 PMID: 23792186
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2013Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. DIABETES. 62:3350-3361.Full Text via DOI: 10.2337/db13-0500 PMID: 23835334
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2013Concurrent Physical Activity Modifies the Association between n3 Long-Chain Fatty Acids and Cardiometabolic Risk in Mid life Adults. JOURNAL OF NUTRITION. 143:1414-1420.Full Text via DOI: 10.3945/jn.113.174078 PMID: 23884386
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2013High energy expenditure masks low physical activity in obesity. INTERNATIONAL JOURNAL OF OBESITY. 37:1006-1011.Full Text via DOI: 10.1038/ijo.2012.172 PMID: 23090575
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2013Mitochondrial Deficiency Is Associated With Insulin Resistance. DIABETES. 62:1032-1035.Full Text via DOI: 10.2337/db12-1612 PMID: 23520282
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2013Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 68:447-455.Full Text via DOI: 10.1093/gerona/gls196 PMID: 23051977
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2012Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults. METABOLISM-CLINICAL AND EXPERIMENTAL. 61:1589-1597.Full Text via DOI: 10.1016/j.metabol.2012.04.012 PMID: 22579053
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2012Femoral-gluteal adiposity is not associated with insulin sensitivity in Type 1 diabetes. DIABETIC MEDICINE. 29:1407-1411.Full Text via DOI: 10.1111/j.1464-5491.2012.03728.x PMID: 22672227
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2012PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 303:E1134-E1141.Full Text via DOI: 10.1152/ajpendo.00282.2012 PMID: 22967498
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2012Total and Abdominal Adiposity Are Associated With Inflammation in Older Adults Using a Factor Analysis Approach. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 67:1099-1106.Full Text via DOI: 10.1093/gerona/gls077 PMID: 22451470
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2012Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 1817:1691-1700.Full Text via DOI: 10.1016/j.bbabio.2012.05.012 PMID: 22659402
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2012Role of intramyocelluar lipids in human health. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 391-398.Full Text via DOI: 10.1016/j.tem.2012.05.009 PMID: 22721584
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2012Do Acute Exercise and Diet Reveal the Molecular Basis for Metabolic Flexibility in Skeletal Muscle?. DIABETES. 983-983.Full Text via DOI: 10.2337/db12-0152 PMID: 22517651
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2012Exercise Dose and Insulin Sensitivity: Relevance for Diabetes Prevention. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 44:793-799.Full Text via DOI: 10.1249/MSS.0b013e31823f679f PMID: 22051572
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2012Lower Thigh Subcutaneous and Higher Visceral Abdominal Adipose Tissue Content Both Contribute to Insulin Resistance. OBESITY. 20:1115-1117.Full Text via DOI: 10.1038/oby.2011.401 PMID: 22262160
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2012Effects of a 12-Month Physical Activity Intervention on Prevalence of Metabolic Syndrome in Elderly Men and Women. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 67:417-424.Full Text via DOI: 10.1093/gerona/glr187 PMID: 22024949
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2012Longitudinal evaluation of cancer-associated biomarkers before and after weight loss in RENEW study participants: Implications for cancer risk reduction. GYNECOLOGIC ONCOLOGY. 125:114-119.Full Text via DOI: 10.1016/j.ygyno.2011.12.439 PMID: 22198242
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2012Muscle strength, mass, and quality in older men and women with knee osteoarthritis. ARTHRITIS CARE & RESEARCH. 64:15-21.Full Text via DOI: 10.1002/acr.20588 PMID: 22213722
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2011SARCOPENIA: BIOMARKERS AND IMAGING (INTERNATIONAL CONFERENCE ON SARCOPENIA RESEARCH). JOURNAL OF NUTRITION HEALTH & AGING. 15:834-846.PMID: 22159770
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2011Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance Another Paradox in Endurance-Trained Athletes?. DIABETES. 60:2588-2597.Full Text via DOI: 10.2337/db10-1221 PMID: 21873552
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2011Validation of an Armband to Measure Daily Energy Expenditure in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 66:1108-1113.Full Text via DOI: 10.1093/gerona/glr101 PMID: 21734231
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2011Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men. METABOLISM-CLINICAL AND EXPERIMENTAL. 60:1178-1185.Full Text via DOI: 10.1016/j.metabol.2010.12.014 PMID: 21353258
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2011Does the Amount of Fat Mass Predict Age-Related Loss of Lean Mass, Muscle Strength, and Muscle Quality in Older Adults?. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 66:888-895.Full Text via DOI: 10.1093/gerona/glr070 PMID: 21572082
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2011The exercise-induced inflammatory and oxidative state paradox. PEDIATRIC DIABETES. 461-463.Full Text via DOI: 10.1111/j.1399-5448.2011.00804.x PMID: 21794044
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2011Effects of Body Composition and Adipose Tissue Distribution on Respiratory Function in Elderly Men and Women: The Health, Aging, and Body Composition Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 66:801-808.Full Text via DOI: 10.1093/gerona/glr059 PMID: 21498841
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2011Clustering of Strength, Physical Function, Muscle, and Adiposity Characteristics and Risk of Disability in Older Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 59:781-787.Full Text via DOI: 10.1111/j.1532-5415.2011.03389.x PMID: 21568948
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2011Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. DIABETOLOGIA. 54:1147-1156.Full Text via DOI: 10.1007/s00125-011-2065-0 PMID: 21327867
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2011F-2-Isoprostanes and Adiposity in Older Adults. OBESITY. 19:861-867.Full Text via DOI: 10.1038/oby.2010.243 PMID: 20948516
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2011Skeletal Muscle Mitochondria in Insulin Resistance: Differences in Intermyofibrillar Versus Subsarcolemmal Subpopulations and Relationship to Metabolic Flexibility. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:494-503.Full Text via DOI: 10.1210/jc.2010-0822 PMID: 21106709
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2011Impact of Weight Loss on Physical Function with Changes in Strength, Muscle Mass, and Muscle Fat Infiltration in Overweight to Moderately Obese Older Adults: A Randomized Clinical Trial. JOURNAL OF OBESITY. 2011.Full Text via DOI: 10.1155/2011/516576 PMID: 20953373
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2010Acute effect of walking on energy intake in overweight/obese women. APPETITE. 55:413-419.Full Text via DOI: 10.1016/j.appet.2010.07.012 PMID: 20674640
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2010Body Fat Distribution and Inflammation Among Obese Older Adults With and Without Metabolic Syndrome. OBESITY. 18:2354-2361.Full Text via DOI: 10.1038/oby.2010.86 PMID: 20395951
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2010Identifying Dysglycemic States in Older Adults: Implications of the Emerging Use of Hemoglobin A1c. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 95:5289-5295.Full Text via DOI: 10.1210/jc.2010-1171 PMID: 20861123
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2010Quantification of Intermuscular Adipose Tissue in the Erector Spinae Muscle by MRI: Agreement With Histological Evaluation. OBESITY. 18:2379-2384.Full Text via DOI: 10.1038/oby.2010.48 PMID: 20300085
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2010Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults A Randomized Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 304:1795-1802.Full Text via DOI: 10.1001/jama.2010.1505 PMID: 20935337
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2010Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 400:318-322.Full Text via DOI: 10.1016/j.bbrc.2010.08.053 PMID: 20727852
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2010Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity. OBESITY. 18:1695-1700.Full Text via DOI: 10.1038/oby.2009.510 PMID: 20111019
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2010Regional adiposity and risk for coronary artery disease in type 1 diabetes: Does having greater amounts of gluteal-femoral adiposity lower the risk?. DIABETES RESEARCH AND CLINICAL PRACTICE. 89:288-295.Full Text via DOI: 10.1016/j.diabres.2010.03.028 PMID: 20413171
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2010Walking in Old Age and Development of Metabolic Syndrome: The Health, Aging, and Body Composition Study. METABOLIC SYNDROME AND RELATED DISORDERS. 8:317-322.Full Text via DOI: 10.1089/met.2009.0090 PMID: 20367219
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2010Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 298:E49-E58.Full Text via DOI: 10.1152/ajpendo.00317.2009 PMID: 19887598
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2010Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content. DIABETES. 59:80-88.Full Text via DOI: 10.2337/db09-0988 PMID: 19833891
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2009Longitudinal study of muscle strength, quality, and adipose tissue infiltration. AMERICAN JOURNAL OF CLINICAL NUTRITION. 90:1579-1585.Full Text via DOI: 10.3945/ajcn.2009.28047 PMID: 19864405
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2009Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes. DIABETES CARE. 32:1993-1997.Full Text via DOI: 10.2337/dc09-0264 PMID: 19549734
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2009Sensory and Motor Peripheral Nerve Function and Lower-Extremity Quadriceps Strength: The Health, Aging and Body Composition Study. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 57:2004-2010.Full Text via DOI: 10.1111/j.1532-5415.2009.02487.x PMID: 19793163
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2009Mechanisms of insulin resistance assessed by dynamic in-vivo positron emission tomography imaging. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 12:508-512.Full Text via DOI: 10.1097/MCO.0b013e32832eb59a PMID: 19550312
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2009Greater Adipose Tissue Infiltration in Skeletal Muscle among Older Men of African Ancestry. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 94:2735-2742.Full Text via DOI: 10.1210/jc.2008-2541 PMID: 19454588
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2009Physical Inactivity and Obesity Underlie the Insulin Resistance of Aging. DIABETES CARE. 32:1547-1549.Full Text via DOI: 10.2337/dc09-0267 PMID: 19401446
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2009Association of the CPT1B Gene with Skeletal Muscle Fat Infiltration in Afro-Caribbean Men. OBESITY. 17:1396-1401.Full Text via DOI: 10.1038/oby.2008.677 PMID: 19553926
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2009Inflammation and Race and Gender Differences in Computerized Tomography-measured Adipose Depots. OBESITY. 17:1062-1069.Full Text via DOI: 10.1038/oby.2008.627 PMID: 19165157
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2009Moderate Exercise Attenuates the Loss of Skeletal Muscle Mass That Occurs With Intentional Caloric Restriction-Induced Weight Loss in Older, Overweight to Obese Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 64:575-580.Full Text via DOI: 10.1093/gerona/glp007 PMID: 19276190
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2009Whole body overexpression of PGC-1 alpha has opposite effects on hepatic and muscle insulin sensitivity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 296:E945-E954.Full Text via DOI: 10.1152/ajpendo.90292.2008 PMID: 19208857
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2009Improvements in Insulin Sensitivity Are Blunted by Subclinical Hypothyroidism. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 41:265-269.Full Text via DOI: 10.1249/MSS.0b013e318187c010 PMID: 19127201
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2009Chronotype and Body Composition in Bipolar Disorder. CHRONOBIOLOGY INTERNATIONAL. 26:780-788.Full Text via DOI: 10.1080/07420520902929060 PMID: 19444756
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2009Metabolic Syndrome and Physical Decline in Older Persons: Results from the Health, Aging and Body Composition Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 64:96-102.Full Text via DOI: 10.1093/gerona/gln005 PMID: 19164274
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2009Physical Activity as a Preventative Factor for Frailty: The Health, Aging, and Body Composition Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 64:61-68.Full Text via DOI: 10.1093/gerona/gln001 PMID: 19164276
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2008A Prospective Observational Study of Obesity, Body Composition, and Insulin Resistance in 18 Women With Bipolar Disorder and 17 Matched Control Subjects. JOURNAL OF CLINICAL PSYCHIATRY. 69:1892-1900.PMID: 19026257
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2008Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial. JOURNAL OF APPLIED PHYSIOLOGY. 105:1498-1503.Full Text via DOI: 10.1152/japplphysiol.90425.2008 PMID: 18818386
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2008Exercise Training and Plasma C-Reactive Protein and Interleukin-6 in Elderly People. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 56:2045-2052.Full Text via DOI: 10.1111/j.1532-5415.2008.01994.x PMID: 19016938
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2008Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation. JOURNAL OF APPLIED PHYSIOLOGY. 105:825-831.Full Text via DOI: 10.1152/japplphysiol.90384.2008 PMID: 18617627
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2008The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults - The Health, Aging, and Body Composition (Health ABC) Study. DIABETES CARE. 31:1767-1772.Full Text via DOI: 10.2337/dc08-0433 PMID: 18535192
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2008Adipose tissue infiltration in skeletal muscle: age patterns and association with diabetes among men of African ancestry. AMERICAN JOURNAL OF CLINICAL NUTRITION. 87:1590-1595.PMID: 18541544
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2008Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 294:E882-E888.Full Text via DOI: 10.1152/ajpendo.00769.2007 PMID: 18319352
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2008The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 63:414-419.PMID: 18426966
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2008Low testosterone bevels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies. CLINICAL ENDOCRINOLOGY. 68:42-50.Full Text via DOI: 10.1111/j.1365-2265.2007.02997.x PMID: 17666086
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2007Activity adherence and physical function in older adults with functional limitations. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 39:1997-2004.Full Text via DOI: 10.1249/mss.0b013e318145348d PMID: 17986908
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2007Neuromuscular electrical stimulation and volitional exercise for individuals with rheumatoid arthritis: A multiple-patient case report. PHYSICAL THERAPY. 87:1064-1077.Full Text via DOI: 10.2522/ptj.20060123 PMID: 17553920
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2007Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity. JOURNAL OF APPLIED PHYSIOLOGY. 103:21-27.Full Text via DOI: 10.1152/japplphysiol.01228.2006 PMID: 17332268
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2007Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes - The Health, Aging, and Body Composition Study. DIABETES CARE. 30:1507-1512.Full Text via DOI: 10.2337/dc06-2537 PMID: 17363749
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2007Discontinuing hormone replacement therapy - Attenuating the effect on CVD risk with lifestyle changes. AMERICAN JOURNAL OF PREVENTIVE MEDICINE. 32:483-489.Full Text via DOI: 10.1016/j.amepre.2007.02.019 PMID: 17533063
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2007Body mass index and serum leptin concentration independently estimate percentage body fat in older adults. AMERICAN JOURNAL OF CLINICAL NUTRITION. 85:1121-1126.PMID: 17413114
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2007Reduced physical activity increases intermuscular adipose tissue in healthy young adults. AMERICAN JOURNAL OF CLINICAL NUTRITION. 85:377-384.PMID: 17284732
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2007Associations among walking performance, physical activity, and subclinical cardiovascular disease.. Preventive cardiology. 134-40.PMID: 17617776
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2006The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 61:1059-1064.PMID: 17077199
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2006Assessment of intramuscular triglycerides: contribution to metabolic abnormalities. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 9:553-559.PMID: 16912550
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2006Diabetes, inflammation, and functional decline in older adults - Findings from the health, aging and body composition (ABC) study. DIABETES CARE. 29:2039-2045.Full Text via DOI: 10.2337/dc06-0245 PMID: 16936150
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2006Daily activity energy expenditure and mortality among older adults. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 296:171-179.PMID: 16835422
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2006Decreased muscle strength and quality in older adults with type 2 diabetes - The health, aging, and body composition study. DIABETES. 55:1813-1818.Full Text via DOI: 10.2337/db05-1183 PMID: 16731847
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2006Effects of exercise on mitochondrial content and function in aging human skeletal muscle. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 61:534-540.PMID: 16799133
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2006Adipocytokines and incident diabetes mellitus in older adults - The independent effect of plasminogen activator inhibitor 1. ARCHIVES OF INTERNAL MEDICINE. 166:350-356.PMID: 16476877
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2006Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 606-616.Full Text via DOI: 10.1007/s00424-005-1509-0 PMID: 16155759
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2006Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 61:72-77.PMID: 16456196
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2005Estrogen replacement, muscle composition, and physical function: The health ABC study. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 37:1741-1747.Full Text via DOI: 10.1249/01.mss.0000181678.28092.31 PMID: 16260975
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2005Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 82:872-878.PMID: 16210719
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2005Lower serum albumin concentration and change in muscle mass: the Health, Aging and Body Composition Study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 82:531-537.PMID: 16155264
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2005Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 294:691-698.PMID: 16091571
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2005Skeletal muscle fatigue, strength, and quality in the elderly: the Health ABC Study. JOURNAL OF APPLIED PHYSIOLOGY. 99:210-216.Full Text via DOI: 10.1152/japplphysiol.01276.2004 PMID: 15718402
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2005Skeletal muscle lipid and its association with insulin resistance: What is the role for exercise?. EXERCISE AND SPORT SCIENCES REVIEWS. 150-154.PMID: 16006823
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2005Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. ARCHIVES OF INTERNAL MEDICINE. 165:777-783.PMID: 15824297
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2005Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 288:E818-E825.Full Text via DOI: 10.1152/ajpendo.00322.2004 PMID: 15585590
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2005Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 60:324-333.PMID: 15860469
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2005Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. DIABETOLOGIA. 48:301-308.Full Text via DOI: 10.1007/s00125-004-1637-7 PMID: 15660262
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2005Predicting the development of diabetes in older adults - The derivation and validation of a prediction rule. DIABETES CARE. 28:404-408.PMID: 15677800
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2005Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. DIABETES. 54:8-14.PMID: 15616005
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2004Skeletal muscle lipid accumulation in obesity, insulin resistance, and type 2 diabetes. PEDIATRIC DIABETES. 219-226.PMID: 15601366
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2004Exercise training increases intramyocellular lipid and oxidative capacity in older adults. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 287:E857-E862.Full Text via DOI: 10.1152/ajpendo.00459.2003 PMID: 15226098
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2004Insulin-like growth factor-1. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 1962-1963.PMID: 15507082
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2004Serum leptin concentrations and body adipose measures in older black and white adults. AMERICAN JOURNAL OF CLINICAL NUTRITION. 80:576-583.PMID: 15321795
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2004Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. DIABETES CARE. 27:1375-1380.PMID: 15161791
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2004Effects of weight loss and physical activity on muscle lipid content and droplet size. OBESITY RESEARCH. 12:761-769.PMID: 15166296
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2004Skeletal muscle lipid concentration quantified by magnetic resonance imaging. AMERICAN JOURNAL OF CLINICAL NUTRITION. 79:748-754.PMID: 15113711
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2003Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. DIABETES. 52:2191-2197.PMID: 12941756
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2002Measuring body fat distribution and content in humans. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 5:481-487.PMID: 12172470
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2002Effects of obesity on substrate utilization during exercise. OBESITY RESEARCH. 10:575-584.PMID: 12105277
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2002Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?. CURRENT DIABETES REPORTS. 216-22.PMID: 12643176
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2002Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: The health, aging and body composition study. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 50:897-904.PMID: 12028178
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2002Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The health ABC study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 57:M326-M332.PMID: 11983728
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2002Muscle triglyceride and insulin resistance. ANNUAL REVIEW OF NUTRITION. 325-346.Full Text via DOI: 10.1146/annurev.nutr.22.010402.102912 PMID: 12055349
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2001Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 86:5755-5761.PMID: 11739435
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2001Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 86:5412-5419.PMID: 11701715
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2001Fat content in individual muscle fibers of lean and obese subjects. INTERNATIONAL JOURNAL OF OBESITY. 25:1316-1321.PMID: 11571593
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2001Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. JOURNAL OF APPLIED PHYSIOLOGY. 90:2157-2165.PMID: 11356778
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2001Effects of exercise on glucose homeostasis in Type 2 diabetes mellitus. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 33:S495-S501.PMID: 11427776
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2001Skeletal Muscle Triglyceride - An aspect of regional adiposity and insulin resistance. DIABETES CARE. 933-941.PMID: 11347757
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2000Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. JOURNAL OF APPLIED PHYSIOLOGY. 89:104-110.PMID: 10904041
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2000Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 278:E941-E948.PMID: 10780952
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2000Intramuscular lipid content is increased in obesity and decreased by weight loss. METABOLISM-CLINICAL AND EXPERIMENTAL. 49:467-472.PMID: 10778870
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2000Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. AMERICAN JOURNAL OF CLINICAL NUTRITION. 71:885-892.PMID: 10731493
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2000Composition of skeletal muscle evaluated with computed tomography. IN VIVO BODY COMPOSITION STUDIES. 904:18-24.PMID: 10865705
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2000Reexamining the sarcopenia hypothesis - Muscle mass versus muscle strength. IN VIVO BODY COMPOSITION STUDIES. 904:456-461.PMID: 10865789
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1999Effects of physical activity on insulin action and glucose tolerance in obesity. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 31:S619-S623.PMID: 10593537
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1999Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. OBESITY RESEARCH. 7:355-362.PMID: 10440591
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1999Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. DIABETES. 48:839-847.PMID: 10102702
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1997Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. DIABETES. 46:1579-1585.PMID: 9313753
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1996The relationship of sustained exercise training and bone mineral density in aging male runners. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 6:216-221.PMID: 8896094
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1995THERMAL RESPONSES TO SWIMMING IN 3 WATER TEMPERATURES - INFLUENCE OF A WET SUIT. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 27:1014-1021.PMID: 7564968
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Research
principal investigator on
- In vivo mitochondrial response to exercise training in MoTrPAC 2020 - 2024
- Highly sensitive multiplexed targeted mass spectrometric assays of proteins/peptides of significance in obesity research 2019 - 2023
- Study of muscle, mobility, and aging 2018 - 2023
- Molecular Transducers of Physical Activity Clinical Centers - (ExPACT): a Proposed MoTrPAC Clinical Center 2016 - 2022
- Ace Inhibitors Combined with Exercise for hypertensive Seniors 2019 - 2022
- The first Abscisic Acid-Containing Medical Food for Glycemic Control 2019 - 2022
Background
Full Name
- Bret H Goodpaster, PhD
Education
- Ball State University, Muncie, IN
Fellowship
- University of Pittsburgh, Pittsburgh, PA; Maastricht University in the Netherlands,
Contact
primary email
- Research.Institute@AdventHealth.com