Bendell, Johanna C., Zakari, Ahmed, Lang, Evan, Waterhouse, David, Flora, Douglas, Alguire, Kathryn, McCleod, Michael, Peacock, Nancy, Ruehlman, Peter, Lane, Cassie M., Earwood, Chris, Shih, Kent
funding text
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abstract
Purpose: To evaluate efficacy and safety of bevacizumab, pertuzumab, and octreotide depot for advanced neuroendocrine tumors.Methods: Patients received bevacizumab 15mg/kg and pertuzumab 420mg IV q21days with octreotide depot 30mg IM q28days.Results: Toxicities in 43 patients included diarrhea (63%), fatigue (63%), hypertension (44%), and nausea (44%). Reversible G3 hypertension (26%) and LVEF decline (9%) occurred. 7/43 patients achieved objective response (typical carcinoid, 5; pancreatic NET, 2). Median PFS and OS were 6.5 and 26.4months, respectively.Discussion: Bevacizumab, pertuzumab, and octreotide depot was well-tolerated with a 16% ORR. Results in the well-differentiated carcinoid tumors are thought provoking.