Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise Article

International Collaboration

cited authors

  • Covington, Jeffrey D., Tam, Charmaine S., Pasarica, Magdalena, Redman, Leanne M.

funding text

  • This investigation was supported in part by a grant from the Health and Performance Enhancement Division of Pennington Biomedical Research Center (L.M.R.) and a Nutrition Obesity Research Center (NORC) grant NIH 1P30 DK072476 (E.R.). This work utilized the Genomics Core Facility at Pennington Biomedical Research Center, which is supported in part by COBRE (NIH P20 RR021945). C.S.T. is supported by a NHMRC Early Career Fellowship (#1037275). L.M.R. is supported by NIH grant R00HD060762.

abstract

  • Polycystic ovary syndrome (PCOS) is characterized by insulin resistance, elevated circulating leukocytes, and hypothesized to have higher adipose tissue inflammation. Aerobic exercise reduces circulating leukocytes and improves insulin sensitivity in obese individuals, but the effect of exercise on inflammation in PCOS is not known. We investigated circulating leukocytes, insulin sensitivity by euglycemic-hyperinsulinemic clamp, serum pro- and anti-inflammatory markers (hsCRP, TNF-alpha, total and high molecular weight adiponectin), and abdominal subcutaneous adipose tissue (SAT) gene expression of proinflammatory markers in 8 PCOS women and 8 obese control females matched for BMI. Additionally, in a prospective study, the 8 women with PCOS underwent a 16-week aerobic exercise regimen with the same measures performed post-intervention. Compared to controls, white blood cell counts (WBC) were 30% higher (p = 0.04) and circulating total adiponectin levels were 150% lower (p = 0.03) in women with PCOS at baseline/pre-exercise conditions. SAT gene expression of macrophage migration inhibitory factor (MIF, p < 0.01) and interleukin-6 (IL-6, p < 0.05) were also lower in women with PCOS. In response to 16 weeks of aerobic exercise, insulin sensitivity improved (p < 0.01) and WBC counts decreased (p = 0.02). The exercise-induced change in WBC and circulating neutrophils correlated inversely with changes in glucose disposal rate (r = -0.73, p = 0.03; and r = -0.82, p = 0.01, respectively). Aerobic exercise reduced serum leptin (p < 0.05) after 4 weeks, trended to reduce the ratio of leptin-to-high molecular weight adiponectin (p < 0.1) by the 8th week, and significantly increased serum dehydroepiandrosterone sulfate (DHEA-S, p < 0.001) after 16 weeks. In conclusion, women with PCOS have higher circulating leukocytes compared to controls, which can be reversed by aerobic exercise and is associated with improvements in insulin sensitivity. (C) 2014 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

Publication Date

  • May 1, 2016

webpage

published in

category

start page

  • 27

end page

  • 33

volume

  • 124

WoS Citations

  • 5

WoS References

  • 58