Bigsby, Glenn E., Holloway, Robert W., Ahmad, Sarfraz, Sombeck, Michael D., Ebra, George, Finkler, Neil J.
abstract
To review outcomes of patients with stage IB-2 cervical carcinoma treated with chemoradiation therapy (CRT) followed by total abdominal hysterectomy (TAH), common iliac and para-aortic lymphadenectomy (PAL). A retrospective review of patients with stage IB-2 cervical cancer treated with CRT followed by TAH/PAL from 1999 to 2009 was performed. Brachytherapy was limited to 1,5001,800 cGy. Sixty-nine patients were identified. The mean age was 46.7 years, tumor diameter 5.4 cm, and all patients had complete clinical response to CRT. The mean follow-up was 61.7 months. There were no central pelvic relapses and two pelvic sidewall failures (97% pelvic control). The mean time to progression was 31.6 months, and 5-year disease-specific survival was 81%. Three (4.3%) patients developed symptomatic vaginal stenosis. CRT plus adjuvant hysterectomy for stage IB-2 cervical cancer resulted in excellent pelvic control and 5-year survival. Vaginal stenosis was rare.