visualizations
Corbin, Karen Davidowitz, PhD, RD
Overview
overview
- Dr. Corbin is an Associate Investigator at the AdventHealth Translational Research Institute. Her program of research focuses on nutrition and metabolism. She studies mechanisms, particularly the gut microbiome, that drive individual susceptibility to metabolic diseases such as obesity, diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). Dr. Corbin’s research portfolio includes both investigator-initiated and industry clinical-translational studies focused on novel pathogenic mechanisms and therapeutics. Her ultimate goal is to advance clinically relevant research that is poised to transform patient care. Dr. Corbin came to the TRI-MD after a 3-year term as a Research Assistant Professor at UNC Chapel Hill, Gillings School of Global Public Health, Department of Nutrition. This was preceded by her postdoctoral training also at UNC Chapel Hill. Dr. Corbin earned her doctorate degree in molecular medicine at the University of South Florida College of Medicine in 2008. She became a registered dietitian in 1998 after completing her dietetic internship at the James A. Haley Veteran’s Hospital in Tampa, FL. She earned her Bachelor’s Degree in Nutrition and Food Science in 1997 at Florida State University.
Affiliation
Member of
-
Clinical Program
-
Research Department
Publications
Most Recent Publications
-
202424-h energy expenditure in people with type 1 diabetes: impact on equations for clinical estimation of energy expenditure. EUROPEAN JOURNAL OF CLINICAL NUTRITION.Full Text via DOI: 10.1038/s41430-024-01446-4 PMID: 38745052
-
2024Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae047 PMID: 38366047
-
2023The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes. FRONTIERS IN ENDOCRINOLOGY. 14.Full Text via DOI: 10.3389/fendo.2023.1219293 PMID: 37576973
-
2023Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial. NATURE COMMUNICATIONS. 14.Full Text via DOI: 10.1038/s41467-023-38778-x PMID: 37258525
-
2023An Overview of Diet and Physical Activity for Healthy Weight in Adolescents and Young Adults with Type 1 Diabetes: Lessons Learned from the ACT1ON Consortium. NUTRIENTS. 15.Full Text via DOI: 10.3390/nu15112500 PMID: 37299463
-
2023Indices of hepatic steatosis and fibrosis in prediabetes and association with diabetes development in the vitamin D and type 2 diabetes study*. JOURNAL OF DIABETES AND ITS COMPLICATIONS. 37.Full Text via DOI: 10.1016/j.jdiacomp.2023.108475 PMID: 37104979
-
2023Associations of Dietary Intake with the Intestinal Microbiota and Short-Chain Fatty Acids Among Young Adults with Type 1 Diabetes and Overweight or Obesity. JOURNAL OF NUTRITION. 153:1178-1188.Full Text via DOI: 10.1016/j.tjnut.2022.12.017 PMID: 36841667
-
2023Measurement of 24-h continuous human CH4 release in a whole room indirect calorimeter. JOURNAL OF APPLIED PHYSIOLOGY. 134:766-776.Full Text via DOI: 10.1152/japplphysiol.00705.2022 PMID: 36794690
-
2023Associations of disordered eating with the intestinal microbiota and short-chain fatty acids among young adults with type 1 diabetes. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 33:388-398.Full Text via DOI: 10.1016/j.numecd.2022.11.017 PMID: 36586772
-
2023Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. DIABETES RESEARCH AND CLINICAL PRACTICE. 197.Full Text via DOI: 10.1016/j.diabres.2023.110565 PMID: 36736734
-
2023Glucagon-like peptide-1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial. OBESITY. 31:350-362.Full Text via DOI: 10.1002/oby.23633 PMID: 36695055
-
2022Cardiorenal outcomes by indices of liver steatosis and fibrosis in individuals with type 2 diabetes and atherosclerotic cardiovascular disease: Analyses from VERTIS CV, a randomized trial of the sodium-glucose cotransporter-2 inhibitor ertugliflozin. DIABETES OBESITY & METABOLISM. 25:758-766.Full Text via DOI: 10.1111/dom.14923 PMID: 36394384
-
2022Relationship Between Moderate-to-Vigorous Physical Activity and Glycemia Among Young Adults with Type 1 Diabetes and Overweight or Obesity: Results from the Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) Study. DIABETES TECHNOLOGY & THERAPEUTICS. 24:881-891.Full Text via DOI: 10.1089/dia.2022.0253 PMID: 35984327
-
2022Weight management in young adults with type 1 diabetes: The advancing care for type 1 diabetes and obesity network sequential multiple assignment randomized trial pilot results. DIABETES OBESITY & METABOLISM.Full Text via DOI: 10.1111/dom.14911 PMID: 36314293
-
2022The Intestinal Microbiota and Short-Chain Fatty Acids in Association with Advanced Metrics of Glycemia and Adiposity Among Young Adults with Type 1 Diabetes and Overweight or Obesity. CURRENT DEVELOPMENTS IN NUTRITION. 6.Full Text via DOI: 10.1093/cdn/nzac107 PMID: 36349343
-
2022More hypoglycemia not associated with increasing estimated adiposity in youth with type 1 diabetes. PEDIATRIC RESEARCH. 93:708-714.Full Text via DOI: 10.1038/s41390-022-02129-1 PMID: 35729217
-
2022Design of the Advancing Care for Type 1 Diabetes and Obesity Network energy metabolism and sequential multiple assignment randomized trial nutrition pilot studies: An integrated approach to develop weight management solutions for individuals with type 1 diabetes.. Contemporary clinical trials. 106765.Full Text via DOI: 10.1016/j.cct.2022.106765 PMID: 35460915
-
2021Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training. DIABETOLOGIA.Full Text via DOI: 10.1007/s00125-021-05535-y PMID: 34402932
-
2021Reliability of measurements of energy expenditure and substrate oxidation using whole-room indirect calorimetry. OBESITY.Full Text via DOI: 10.1002/oby.23226 PMID: 34355521
-
2021Developing a model for estimating the activity of colonic microbes after intestinal surgeries. PLOS ONE. 16.Full Text via DOI: 10.1371/journal.pone.0253542 PMID: 34319981
-
2021Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial. OBESITY SCIENCE & PRACTICE.Full Text via DOI: 10.1002/osp4.486 PMID: 34123395
-
2021Chemical Oxygen Demand Can Be Converted to Gross Energy for Food Items Using a Linear Regression Model. JOURNAL OF NUTRITION. 151:445-453.Full Text via DOI: 10.1093/jn/nxaa321 PMID: 33188419
-
2021Weight Loss and Weight Regain in Usual Clinical Practice: Results From the TARGET-NASH Observational Cohort.. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.Full Text via DOI: 10.1016/j.cgh.2021.01.023 PMID: 33486083
-
2021Metabolic adaptation characterizes short-term resistance to weight loss induced by a low-calorie diet in overweight/obese individuals.. The American journal of clinical nutrition. 267-280.Full Text via DOI: 10.1093/ajcn/nqab027 PMID: 33826697
-
2020Dietary intake on days with and without hypoglycemia in youth with type 1 diabetes: The Flexible Lifestyle Empowering Change trial. PEDIATRIC DIABETES. 21:1475-1484.Full Text via DOI: 10.1111/pedi.13132 PMID: 32981192
-
2020Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance. CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS. 19.Full Text via DOI: 10.1016/j.conctc.2020.100646 PMID: 32875141
-
2018Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms. ENDOCRINE REVIEWS. 629-663.Full Text via DOI: 10.1210/er.2017-00191 PMID: 30060120
-
2017Biopsychosocial Aspects of Weight Management in Type 1 Diabetes: a Review and Next Steps. CURRENT DIABETES REPORTS.Full Text via DOI: 10.1007/s11892-017-0892-1 PMID: 28660565
-
2016Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders. REPRODUCTIVE TOXICOLOGY. 59:101-108.Full Text via DOI: 10.1016/j.reprotox.2015.11.006 PMID: 26656914
-
2015Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis. NUTRITION RESEARCH. 35:939-947.Full Text via DOI: 10.1016/j.nutres.2015.09.004 PMID: 26439440
-
2015Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. FASEB JOURNAL. 29:3426-3435.Full Text via DOI: 10.1096/fj.15-271056 PMID: 25921832
-
2014Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 100:778-786.Full Text via DOI: 10.3945/ajcn.114.087692 PMID: 24944063
-
2014Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. REPRODUCTIVE TOXICOLOGY. 46:31-39.Full Text via DOI: 10.1016/j.reprotox.2014.02.002 PMID: 24568797
-
2014Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. FASEB JOURNAL. 28:2970-2978.Full Text via DOI: 10.1096/fj.14-249557 PMID: 24671709
-
2013Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB JOURNAL. 27:1674-1689.Full Text via DOI: 10.1096/fj.12-219097 PMID: 23292069
-
2012Protein Kinase C alpha Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 during Calcium-dependent Stimulation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:26168-26176.Full Text via DOI: 10.1074/jbc.M112.378794 PMID: 22696221
-
2012Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 421:9-14.Full Text via DOI: 10.1016/j.bbrc.2012.03.074 PMID: 22452988
-
2012Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. CURRENT OPINION IN GASTROENTEROLOGY. 159-165.Full Text via DOI: 10.1097/MOG.0b013e32834e7b4b PMID: 22134222
-
2012The Nutrigenetics and Nutrigenomics of the Dietary Requirement for Choline. RECENT ADVANCES IN NUTRIGENETICS AND NUTRIGENOMICS. 159-177.Full Text via DOI: 10.1016/B978-0-12-398397-8.00007-1 PMID: 22656377
-
2011A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate for 14 Hours. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 43:1643-1648.Full Text via DOI: 10.1249/MSS.0b013e3182118891 PMID: 21311363
-
2008Phosphorylation of argininosuccinate synthase by protein kinase A. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 377:1042-1046.Full Text via DOI: 10.1016/j.bbrc.2008.10.056 PMID: 18948083
-
2008Troglitazone up-regulates vascular endothelial argininosuccinate synthase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 370:254-258.Full Text via DOI: 10.1016/j.bbrc.2008.03.089 PMID: 18375203
Background
Full Name
- Karen Davidowitz Corbin, PhD
Education
- University of South Florida College of Medicine
Fellowship
- James A. Haley Veteran's Hospital, Tampa, FL
Contact
primary email
- Research.Institute@AdventHealth.com