visualizations
Distefano, Giovanna, PhD, PT
Overview
Affiliation
Member of
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Clinical Program
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Research Department
Publications
Most Recent Publications
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2024Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. FREE RADICAL BIOLOGY AND MEDICINE. 223:384-397.Full Text via DOI: 10.1016/j.freeradbiomed.2024.07.039 PMID: 39097206
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2024Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis. ARTHRITIS & RHEUMATOLOGY.Full Text via DOI: 10.1002/art.42953 PMID: 39016102
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2024Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). JOURNAL OF SPORT AND HEALTH SCIENCE. 13:621-630.Full Text via DOI: 10.1016/j.jshs.2024.02.001 PMID: 38341136
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2024Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glae101 PMID: 38605684
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2024Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. OBESITY. 32:1125-1135.Full Text via DOI: 10.1002/oby.24008 PMID: 38803308
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2024Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79.Full Text via DOI: 10.1093/gerona/glad283 PMID: 38150179
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2023ASSOCIATION OF DIABETES WITH BODY COMPOSITION, CARDIORESPIRATORY FITNESS, AND MITOCHONDRIAL ENERGETICS. INNOVATION IN AGING. 640-640.
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2023CARDIORESPIRATORY FITNESS AND MITOCHONDRIAL ENERGETICS IN THE OLDEST OLD: THE STUDY OF MUSCLE, MOBILITY AND AGING. INNOVATION IN AGING. 639-639.
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2023GENDER DIFFERENCES IN SKELETAL MUSCLE ENERGETICS EXPLAIN THE MOBILITY IMPAIRMENT DISPARITY IN SOMMA. INNOVATION IN AGING. 639-639.
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2023Reduced Muscle Energetics And Fitness In Older Adults With Diabetes Independent Of Adiposity And Activity. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 166-166.
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2023Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults. JOURNAL OF PHYSIOLOGY-LONDON.Full Text via DOI: 10.1113/JP284142 PMID: 36814134
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2022Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.Full Text via DOI: 10.1093/gerona/glac238 PMID: 36462195
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2022PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS. INNOVATION IN AGING. 209-209.
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2022SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS. INNOVATION IN AGING. 808-808.
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2021Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training. DIABETOLOGIA.Full Text via DOI: 10.1007/s00125-021-05535-y PMID: 34402932
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2020Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 75:1744-1753.Full Text via DOI: 10.1093/gerona/glaa001 PMID: 31907525
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2019Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI INSIGHT. 4.Full Text via DOI: 10.1172/jci.insight.128248 PMID: 31120438
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2019Changes On Non-exercise Physical Activity Are Related To Improvements In Mitochondrial Function Independently Of Structured Intentional Exercise. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 773-773.
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201812,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake (vol 27, pg 1111, 2018). CELL METABOLISM. 1357-1357.Full Text via DOI: 10.1016/j.cmet.2018.04.023 PMID: 29874569
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201812,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. CELL METABOLISM. 27:1111-+.Full Text via DOI: 10.1016/j.cmet.2018.03.020 PMID: 29719226
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2018Nitrite Improves Skeletal Muscle Mitochondrial Coupling and Walking Efficiency in Older Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S6-S6.
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2018Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 9:279-294.Full Text via DOI: 10.1002/jcsm.12272 PMID: 29368427
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2018Effects of Exercise and Aging on Skeletal Muscle. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 8.Full Text via DOI: 10.1101/cshperspect.a029785 PMID: 28432116
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2017Effects of beta-hydroxy-beta-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. JOURNAL OF APPLIED PHYSIOLOGY. 123:1092-1100.Full Text via DOI: 10.1152/japplphysiol.00192.2017 PMID: 28705993
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2017Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 72:535-542.Full Text via DOI: 10.1093/gerona/glw102 PMID: 27325231
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2017Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. EXPERIMENTAL GERONTOLOGY. 90:1-13.Full Text via DOI: 10.1016/j.exger.2017.01.013 PMID: 28108329
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2015Dose Response of Exercise Training Following Roux-en-Y Gastric Bypass Surgery: A Randomized Trial. OBESITY. 23:2454-2461.Full Text via DOI: 10.1002/oby.21332 PMID: 26537198
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2015Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery. DIABETES. 64:3737-3750.Full Text via DOI: 10.2337/db15-0809 PMID: 26293505
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2014Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 307:E1117-E1124.Full Text via DOI: 10.1152/ajpendo.00257.2014 PMID: 25352435
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2014Racial Differences In Peripheral Insulin Sensitivity and Mitochondrial Capacity in the Absence of Obesity. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:4307-4314.Full Text via DOI: 10.1210/jc.2014-2512 PMID: 25105736
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2014Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. FREE RADICAL BIOLOGY AND MEDICINE. 74:64-73.Full Text via DOI: 10.1016/j.freeradbiomed.2014.06.012 PMID: 24960579
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2014Regular Exercise Improves Insulin Sensitivity and Muscle Mitochondrial Respiration Following Gastric Bypass Surgery. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 794-795.
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2014Skeletal Muscle Mitochondrial Respiration And Expression Of Quality Control Proteins Are Unaffected By Aging. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 298-298.
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2013Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. DIABETES. 62:3350-3361.Full Text via DOI: 10.2337/db13-0500 PMID: 23835334
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2013Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 68:447-455.Full Text via DOI: 10.1093/gerona/gls196 PMID: 23051977
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2012A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/3914 PMID: 22617846
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2010The Synergistic Effect of Treadmill Running on Stem-Cell Transplantation to Heal Injured Skeletal Muscle. TISSUE ENGINEERING PART A. 16:839-849.Full Text via DOI: 10.1089/ten.tea.2009.0113 PMID: 19788347
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2008The onset and duration of mobilization affect the regeneration in the rat muscle. HISTOLOGY AND HISTOPATHOLOGY. 23:565-571.PMID: 18283641
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1978EFFECT OF PRIMING OF AMINO-ACIDS ON INSULIN AND GROWTH-HORMONE RESPONSE IN PREMATURE-INFANT. DIABETES. 27:334-337.PMID: 640239
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1975EFFECT OF GLUCOSE PRIMING ON INSULIN-RESPONSE IN PREMATURE-INFANT. DIABETES. 24:291-294.PMID: 1116652
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1973INSULIN-SECRETION IN PREMATURE-INFANT - RESPONSE TO GLUCOSE AND AMINO-ACIDS. DIABETES. 22:349-353.PMID: 4700048
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1971SERUM INSULIN AND GROWTH HORMONE RESPONSE TO ARGININE AND TO ARGININE WITH GLUCOSE IN PREMATURE INFANT. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 33:924-+.PMID: 5135634
Research
principal investigator on
Background
Full Name
- Giovanna Distefano, PhD
Education
- University of Pittsburgh School of Health and Rehabilitation Sciences
Contact
primary email
- Research.Institute@AdventHealth.com