Distefano, Giovanna, PT, PhD

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Distefano, Giovanna, PT, PhD
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Clinical Program
- Muscle Metabolism, Aging and Exercise
Research Department
- Translational Research Institute

Most Recent Publications

2023

Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults. JOURNAL OF PHYSIOLOGY-LONDON.
Full Text via DOI: 10.1113/JP284142 PMID: 36814134
2022

Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.
Full Text via DOI: 10.1093/gerona/glac238 PMID: 36462195
2022

PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS. INNOVATION IN AGING. 209-209.
2022

SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS. INNOVATION IN AGING. 808-808.
2021

Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training. DIABETOLOGIA.
Full Text via DOI: 10.1007/s00125-021-05535-y PMID: 34402932
2020

Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 75:1744-1753.
Full Text via DOI: 10.1093/gerona/glaa001 PMID: 31907525
2019

Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI INSIGHT. 4.
Full Text via DOI: 10.1172/jci.insight.128248 PMID: 31120438
2019

Changes On Non-exercise Physical Activity Are Related To Improvements In Mitochondrial Function Independently Of Structured Intentional Exercise. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 773-773.
2018

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake (vol 27, pg 1111, 2018). CELL METABOLISM. 1357-1357.
Full Text via DOI: 10.1016/j.cmet.2018.04.023 PMID: 29874569
2018

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. CELL METABOLISM. 27:1111-+.
Full Text via DOI: 10.1016/j.cmet.2018.03.020 PMID: 29719226
2018

Nitrite Improves Skeletal Muscle Mitochondrial Coupling and Walking Efficiency in Older Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S6-S6.
2018

Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 9:279-294.
Full Text via DOI: 10.1002/jcsm.12272 PMID: 29368427
2018

Effects of Exercise and Aging on Skeletal Muscle. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 8.
Full Text via DOI: 10.1101/cshperspect.a029785 PMID: 28432116
2017

Effects of beta-hydroxy-beta-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. JOURNAL OF APPLIED PHYSIOLOGY. 123:1092-1100.
Full Text via DOI: 10.1152/japplphysiol.00192.2017 PMID: 28705993
2017

Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 72:535-542.
Full Text via DOI: 10.1093/gerona/glw102 PMID: 27325231
2017

Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. EXPERIMENTAL GERONTOLOGY. 90:1-13.
Full Text via DOI: 10.1016/j.exger.2017.01.013 PMID: 28108329
2015

Dose Response of Exercise Training Following Roux-en-Y Gastric Bypass Surgery: A Randomized Trial. OBESITY. 23:2454-2461.
Full Text via DOI: 10.1002/oby.21332 PMID: 26537198
2015

Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery. DIABETES. 64:3737-3750.
Full Text via DOI: 10.2337/db15-0809 PMID: 26293505
2014

Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 307:E1117-E1124.
Full Text via DOI: 10.1152/ajpendo.00257.2014 PMID: 25352435
2014

Racial Differences In Peripheral Insulin Sensitivity and Mitochondrial Capacity in the Absence of Obesity. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:4307-4314.
Full Text via DOI: 10.1210/jc.2014-2512 PMID: 25105736
2014

Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. FREE RADICAL BIOLOGY AND MEDICINE. 74:64-73.
Full Text via DOI: 10.1016/j.freeradbiomed.2014.06.012 PMID: 24960579
2014

Regular Exercise Improves Insulin Sensitivity and Muscle Mitochondrial Respiration Following Gastric Bypass Surgery. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 794-795.
2014

Skeletal Muscle Mitochondrial Respiration And Expression Of Quality Control Proteins Are Unaffected By Aging. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 298-298.
2013

Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. DIABETES. 62:3350-3361.
Full Text via DOI: 10.2337/db13-0500 PMID: 23835334
2013

Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 68:447-455.
Full Text via DOI: 10.1093/gerona/gls196 PMID: 23051977
2013

Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted into Dystrophic Skeletal Muscle. PLOS ONE. 8.
Full Text via DOI: 10.1371/journal.pone.0054922 PMID: 23526927
2012

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
Full Text via DOI: 10.3791/3914 PMID: 22617846
2010

The Synergistic Effect of Treadmill Running on Stem-Cell Transplantation to Heal Injured Skeletal Muscle. TISSUE ENGINEERING PART A. 16:839-849.
Full Text via DOI: 10.1089/ten.tea.2009.0113 PMID: 19788347
2008

The onset and duration of mobilization affect the regeneration in the rat muscle. HISTOLOGY AND HISTOPATHOLOGY. 23:565-571.
PMID: 18283641
1978

EFFECT OF PRIMING OF AMINO-ACIDS ON INSULIN AND GROWTH-HORMONE RESPONSE IN PREMATURE-INFANT. DIABETES. 27:334-337.
PMID: 640239
1975

EFFECT OF GLUCOSE PRIMING ON INSULIN-RESPONSE IN PREMATURE-INFANT. DIABETES. 24:291-294.
PMID: 1116652
1973

INSULIN-SECRETION IN PREMATURE-INFANT - RESPONSE TO GLUCOSE AND AMINO-ACIDS. DIABETES. 22:349-353.
PMID: 4700048
1971

SERUM INSULIN AND GROWTH HORMONE RESPONSE TO ARGININE AND TO ARGININE WITH GLUCOSE IN PREMATURE INFANT. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 33:924-+.
PMID: 5135634

principal investigator on

missing activity

Full Name

Giovanna Distefano, PT, PhD

Education

University of Pittsburgh School of Health and Rehabilitation Sciences

primary email

Research.Institute@AdventHealth.com