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Casu, Anna, MD
Overview
overview
- Dr. Anna Casu is Associate Investigator at the Translational Research Institute and Von Weller Family Chair in Type 1 Diabetes Research. Her research focuses on type 1 diabetes (T1D) epidemiology, prediction, and pathogenic mechanisms linked to the relationship between the exocrine and endocrine pancreas and the onset of T1D in adults. She obtained her medical degree and completed her residency and fellowship in endocrinology at the University of Cagliari, Sardinia, Italy, when she published articles about the world’s second-highest incidence rate of T1D on the island. She became a Post-Doctoral Associate, then Research Associate, at the University of Pittsburgh, then moved back to Italy where she became Chief of the Diabetes and Islet Transplantation Unit and Clinical Assistant Professor of Medicine, University of Pittsburgh Medical Center, both based in Palermo, Italy. There, she established and managed the pancreatic islet transplant unit and program, and her research was funded by the European Union. Leveraging her knowledge of human pancreas biology, Dr. Casu’s current research interest focuses on the relationship between the exocrine and the endocrine pancreas, with an emphasis on cell-to-cell interactions and circulating biomarkers. She is the local principal investigator of the NCI-funded New-Onset Diabetes (NOD) study of the Chronic Pancreatitis Diabetes Pancreatic Cancer Consortium and co-investigator for the NIH/NIDDK funded Type 1 Diabetes in Acute Pancreatitis Consortium, where she serves as co-chair of the Immunology Working Group. She actively collaborates with AdventHealth gastroenterologists and surgeons specializing in caring for patients with disorders of the pancreas.
research areas
Affiliation
Member of
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Clinical Program
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Research Department
Publications
Most Recent Publications
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2024Incretin mimetics and acute pancreatitis: enemy or innocent bystander?. CURRENT OPINION IN GASTROENTEROLOGY. 40:404-412.Full Text via DOI: 10.1097/MOG.0000000000001057 PMID: 38967917
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2024Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study. DIABETES CARE. 47.Full Text via DOI: 10.2337/dc24-0201 PMID: 38713913
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202424-h energy expenditure in people with type 1 diabetes: impact on equations for clinical estimation of energy expenditure. EUROPEAN JOURNAL OF CLINICAL NUTRITION.Full Text via DOI: 10.1038/s41430-024-01446-4 PMID: 38745052
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2023The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes. FRONTIERS IN ENDOCRINOLOGY. 14.Full Text via DOI: 10.3389/fendo.2023.1219293 PMID: 37576973
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2023Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. DIABETES RESEARCH AND CLINICAL PRACTICE. 197.Full Text via DOI: 10.1016/j.diabres.2023.110565 PMID: 36736734
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2022Weight management in young adults with type 1 diabetes: The advancing care for type 1 diabetes and obesity network sequential multiple assignment randomized trial pilot results. DIABETES OBESITY & METABOLISM.Full Text via DOI: 10.1111/dom.14911 PMID: 36314293
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2022The Intestinal Microbiota and Short-Chain Fatty Acids in Association with Advanced Metrics of Glycemia and Adiposity Among Young Adults with Type 1 Diabetes and Overweight or Obesity. CURRENT DEVELOPMENTS IN NUTRITION. 6.Full Text via DOI: 10.1093/cdn/nzac107 PMID: 36349343
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2022Coordinated regulation of gene expression and microRNA changes in adipose tissue and circulating extracellular vesicles in response to pioglitazone treatment in humans with type 2 diabetes. FRONTIERS IN ENDOCRINOLOGY. 13.Full Text via DOI: 10.3389/fendo.2022.955593 PMID: 36120427
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2022Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study From the Type 1 Diabetes in Acute Pancreatitis Consortium. PANCREAS. 51:598-603.Full Text via DOI: 10.1097/MPA.0000000000002072 PMID: 36206465
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2022Closed-loop therapy in older adults with type 1 diabetes: hypoglycaemia benefits and risk stratification. LANCET HEALTHY LONGEVITY. E379-E379.PMID: 36098316
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2022Design of the Advancing Care for Type 1 Diabetes and Obesity Network energy metabolism and sequential multiple assignment randomized trial nutrition pilot studies: An integrated approach to develop weight management solutions for individuals with type 1 diabetes.. Contemporary clinical trials. 106765.Full Text via DOI: 10.1016/j.cct.2022.106765 PMID: 35460915
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2022Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23.Full Text via DOI: 10.3390/ijms23105779 PMID: 35628588
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2022In Vitro Evaluation of Nanoerythrosome Cytotoxicity and Uptake in Pancreatic Endothelial Cells: Implications for beta-Cell Imaging Applications br. LANGMUIR. 38:3403-3411.Full Text via DOI: 10.1021/acs.langmuir.1c03153 PMID: 35262354
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2022Can technology improve the management of older adults with type 1 diabetes? Yes, but... Comment. LANCET HEALTHY LONGEVITY. E120-E121.
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2021Impact of bariatric surgery and weight loss medications in adults with type 1 diabetes in the T1D Exchange Clinic Registry. JOURNAL OF DIABETES AND ITS COMPLICATIONS. 35.Full Text via DOI: 10.1016/j.jdiacomp.2021.107884 PMID: 33610436
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2021Investigation of Extracellular Vesicles From SARS-CoV-2 Infected Specimens: A Safety Perspective. FRONTIERS IN IMMUNOLOGY. 12.Full Text via DOI: 10.3389/fimmu.2021.617042 PMID: 33968019
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2021Surface-modified nanoerythrosomes for potential optical imaging diagnostics. JOURNAL OF COLLOID AND INTERFACE SCIENCE. 582:246-253.Full Text via DOI: 10.1016/j.jcis.2020.08.032 PMID: 32823126
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2020Pharmacological therapies to address obesity in type 1 diabetes. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY. 194-206.Full Text via DOI: 10.1097/MED.0000000000000555 PMID: 32618631
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2020Characteristics of adult- compared to childhood-onset type 1 diabetes. DIABETIC MEDICINE.Full Text via DOI: 10.1111/dme.14314 PMID: 32353892
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2018Carnosine protects pancreatic beta cells and islets against oxidative stress damage. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 474:105-118.Full Text via DOI: 10.1016/j.mce.2018.02.016 PMID: 29496567
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2017Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. DIABETES CARE. 40:561-568.Full Text via DOI: 10.2337/dc16-1527 PMID: 28174261
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2010Humoral Autoimmunity against the Extracellular Domain of the Neuroendocrine Autoantigen IA-2 Heightens the Risk of Type 1 Diabetes. ENDOCRINOLOGY. 151:2528-2537.Full Text via DOI: 10.1210/en.2009-1257 PMID: 20382696
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2009The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial. XENOTRANSPLANTATION. 16:229-238.Full Text via DOI: 10.1111/j.1399-3089.2009.00543.x PMID: 19799763
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2005Epidemiology of childhood diabetes.. Acta bio-medica : Atenei Parmensis. 19-25.PMID: 16915791
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2004Type 1 diabetes among Sardinian children is increasing - The Sardinian diabetes register for children aged 0-14 years (1989-1999). DIABETES CARE. 27:1623-1629.PMID: 15220238
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2004
Background
Full Name
- Anna Casu, MD
Education
- University of Caligari, Italy
Residency
- University of Caligari, Italy
Fellowship
- University of Caligari, Italy
Contact
primary email
- Research.Institute@AdventHealth.com